Shizune

is the assistant of Tsunade and a talented Medic-nin. She is quite close to Tsunade, one of the few people Tsunade would trust with absolute certainty and a fairly talented and capable ninja in her own right.

Background
Shizune is the niece of Dan, the lover of Tsunade. Sometime after Dan died, Tsunade left Konoha and Shizune went with her as her attendant. The bond between Tsunade and Shizune is strong and above all, Shizune sees her purpose in life as caring for Tsunade.

Personality
Unlike Tsunade, she is level-headed, practical, and a rational thinker. As a result, she is the one who tends to stress over details like Tsunade's tendency to gamble and think with her heart. She often gets comically worked up over any irrational decision Tsunade makes. Shizune also looks after Tonton, Tsunade's pet pig.

Search for Tsunade arc
When Orochimaru comes to Tsunade years later in an attempt to get her to heal his arms, Shizune attempted to persuade Tsunade against it, even trying to convince Tsunade to help her kill Orochimaru. When all attempts to persuade Tsunade fail, Shizune tried to use force to stop Tsunade from helping Orochimaru, though Tsunade easily defeats her. She later fought Kabuto Yakushi in an effort to protect an incapacitated Tsunade and Naruto Uzumaki. Despite Shizune's efforts, Kabuto proves too much for her as he easily dodges her attacks and incapacitates her, too. Shizune manages to heal her legs and leaves the field of battle with the unconscious Naruto as the three Sannin prepare to conclude their battle. She then returns to Konoha with Tsunade after she accepts the office of Hokage.

Sasuke Retrieval arc
When Tsunade takes on the title of Hokage, Shizune leads a team consisting of Genma Shiranui, Raido Namiashi, and Iwashi Tatami to compensate for the lack of manpower caused by the invasion of Konoha. When Genma and Raido are defeated by the Sound Four, Shizune heals their wounds. Later, she is seen leading a medical team charged with regenerating the wounds of Neji Hyuga.

Anime Filler arcs
She appears in almost every filler arc as Tsunade's attendant and secretary. During the Mizuki arc, she is defeated by Mizuki, who uses her guise to lead Naruto and Iruka into a trap. She is later seen as part of a reinforcement team with Shikamaru for Naruto, Choji and Hinata during the Land of the Vegetables arc.

Part II
Shizune appears frequently in Part II, often being nearby when Tsunade is issuing orders. She begins to grow concerned by Naruto repeatedly going up against member of Akatsuki, and reports this to the village elders. Although Tsunade is able to reach a compromise with the elders, Shizune doubted Tsunade's wisdom, but she seemed to regain faith later on.

Three-Tails Arrival arc
In the anime, Shizune is assigned to help seal the Three-Tailed Beast, joining the sealing team along with Ino, Sakura, and Hinata. Seeing the beast's sealing as a way to stop Akatsuki's plans, Shizune takes charge of the process, instructing the other members in order to speed along the process. The sealing is repeatedly interrupted by Guren and her men, and the sealing is instead left to ANBU members.

Invasion of Pain arc
After Jiraiya is killed by the Akatsuki leader, Pain, Shizune is left in charge of examining the body he captured. When Shizune discovers that the piercings on the body are chakra receivers, she is given ANBU escorts to ensure she can share the information with as many people as possible. She meets up with Inoichi, but before they can begin to collaborate Shizune is captured by the Human path. It reads her mind to find out that Naruto is at Myobokuzan and then removes her soul, killing her. In the ensuing destruction her body is kept safe and is later revived by Pain's resurrection jutsu.

Abilities
Shizune has rarely been seen fighting in battle but it is apparent that Shizune's attacks are based (ironically due to her medical talents) solely around poison. Being a medical-nin, she has to keep her distance in battle, making sure not to injure herself so she can be of use to heal her teammates later. However, she appears to be quite fast and equally fierce and precise in her attacks, as stated by Kabuto.

Shizune is noted to be a very talented medical ninja, rivaled only by Sakura and Tsunade herself. It has apparently given her excellent chakra control, which is the primary reason she is assigned to help seal the Three-Tailed Beast.

Other Appearances
Shizune is commonly a playable character in the Ultimate Ninja series of games. She is seen be able to create swords out of chakra in a move called "Chakra Swords: Great Cross Slash" that causes both physical damage and internal damage to her opponent and creates a huge explosion. She also has a jutsu called "Hog Style: Tonton" which calls on Tonton to attack Shizune's opponent, hitting the opponent up to 30 times to cause major damage.

Trivia

 * She is one of the few named characters in Naruto to experience death and be brought back to life. The others to have experienced this are Gaara, Kakashi Hatake, and Fukasaku. A lot of other Konoha ninja shared this fate but their names are unknown.

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