Board Thread:Versus Debates/@comment-26104757-20170303072554/@comment-26104757-20170304005156

Wouldn't Mei's Hiding in the Mist technique be enough to defeat him? Since the Sharingan will be weakened, added to his already blind and deaf status, it would leave him entirely open for Tsunade to lower in with her introductory Heavenly Kick of Pain. If he opens MS, and uses Susanoo, Mei can incorporate her vapour and melt his defense, enough for Tsunade to break through.

Mei trumps his Fire power.

Tsunade will likely be able to escape any Genjutsu he uses courtesy of her perfect chakra control.

The only issue I have with Itachi is Amaterasu. Other than that, Tsunade and Mei take this with mid-difficulty.

BTW: How long can Itachi leave his MS open before he kneels over with exhaustion?