Board Thread:Theories and Speculation/@comment-26636534-20150710195521/@comment-734582-20150714081756

QuakingStar wrote: Itachi while deathly sick, was 2.5 tier in chakra... We have no clue what he was like before gaining the terminal disease. For years, by the way. Itachi was sick for a long time but fought it so he could fight Sasuke. Considering that having something as simple as the flu can wreck your stamina, imagine what such a fatal disease has done.

Knight504 wrote: Pain said that Kisame had a large amount of chakra even for an Akatsuki member. He wasn't talking about Itachi at all. Itachi and Kisame were chosen for the Substitute during the Gaara Rescue because they had the most chakra of Akatsuki.