Board Thread:Naruto Gaiden/@comment-25380140-20150514070725/@comment-3965545-20150514233254

No, Shisui loved Itachi as a brother and the best friend he ever had. DB4 confirms they were raised together/grew up together. He was closer to Itachi than he was to Sasuke and he knew the truth behind Itachi's actions. There's a high chance he could hate Sasuke for pushing Itachi into killing himself. As Orochimaru said quite clearly, some people change and it's not always for the best.