Board Thread:Naruto Discussions/@comment-25866907-20150220224824/@comment-25937220-20150221011121

Tsunade and Naruto are distantly related. She is the descendant of the Senju and Uzumaki Clan, her grandfather is Hashirama Senju and her grandmother is Mito Uzumaki. And we know that the Senju Clan descended from the Sage of the Six Paths, thus meaning so do the Uzumaki Clan, as they are distant blood relatives of the Senju. Thus, proving Tsunade is related to Naruto, but not as distant as you may think.