Board Thread:Naruto Discussions/@comment-25219329-20150128075931/@comment-25219329-20150408183018

i was saying, maybe thats why we dont see any of the senju, if we consider how sick some of the characters in the manga/anime were, maybe its possible that there had been a plague in the past, to the point that the senju is on the same level as the uzumaki.

Tsunade's aging is because of when she uses her special jutsu of regeneration, it speeds up the aging process