Board Thread:Theories and Speculation/@comment-26545929-20150630030815/@comment-1751565-20150630031657

Believe it or not, I would have to say Tsunade. She is such a powerhouse, and has that "no time to waste" thing... Plus she has the most reserves of Chakra out of the 3. Personally I say Jiraiya was the weakest only because he was the most "human" out of the 3 and thus had "human" limitations. Tsunade could Regenerate & had Medical jutsus, Orochimaru was immortal...they would be tough for Jiraiya alone to kill them.

As for Orochimaru, he always seemed inferior to Tsunade and against her what he ever boasted alone was his Immortality to be able to take her One-hit Kill punches. Even he himself stated that there was a limit he could take even if he was immortal.