Board Thread:Theories and Speculation/@comment-1872728-20200725151448/@comment-3279282-20200726125803

No, as proven by Orochimaru. He was able to knead senjutsu chakra, but was unable to enter Sage Mode due to his frail host body.

And as I explained when I deleted your thread, please use another place to ask generic questions. If it's not answered in the articles, nobody can give you a definite answer anyway. It's all just speculation.