Board Thread:Versus Debates/@comment-5085906-20180725155538/@comment-5936871-20180726152204

Tsunade, all she needs to do is hit Kisame one time and he literally explodes and dies. He isn't drowning her either, Katsuyu can easily bust Kisame's water dome due to her size and raise Tsunade above the water. Katsuyu can also flood the dome with her acid, which would roast Kisame alive inside of the dome. So no matter how much water Kisame uses it isn't going to help him, Tsunade can either knock the water away with her sheer strength, or Katsuyu can evaporate it with her acid.

He isn't sucking up her chakra either, Tsunade doesn't wear chakra like a second pair of clothes like V2 Killer B did. So it's not going to be so easy for Kisame to do that, he can only do that by having samehada bite Tsunade and that is unlikely to happen since she is more skilled in CQC than he is and him getting that close to her is suicide on his part. Additionally, all of Kisame's Jutsu would be smaller and therefore weaker since he hasn't sucked up a bunch of Gyuki/Killer B's chakra in this scenario. In conclusion, Tsunade wins with mid difficulty.