Curse of Hatred

The is an ideal that was said to be passed down by the Uchiha clan's forefather to its members. This began when the Sage of the Six Paths who was dying decided to name his youngerson, who would go on to become the forefather of the Senju clan his successor instead of the older one because the Sage believed that the beliefs that son held were the key to peace. Consumed with hatred the elder brother eventually clashed with his sibling and thus began the cycle of hatred between the Uchiha and Senju.

Trivia

 * According to Madara Sasuke has inherited the hatred of all the Uchiha and is fated to clash against Naruto who has inherited the Senju's Will of Fire