Board Thread:Versus Debates/@comment-26090777-20150330194229/@comment-26127155-20150402224156

If we don't count Kaguya, Hagoromo, Hamura, and even Asura, Indra, and Toneri (are they ninja?), then I would either go with Itachi & Shisui or Itachi & Kakashi (double Mangekyo).

Itachi & Shisui: They could both just mind control Sasuke & Naruto and then seal them with the totsuka blade. They both have Susanoo which would help them fight against the two characters.

Itachi & Kakashi: Itachi's crow could use it's mangekyo in order to mind control either Sasuke/Naruto and it would leave the fight in being a 1V3. Kakashi's Kamui gives him the ability to both dodge and land critical blows on both Naruto and Sasuke. Kakashi and Itachi both have great knowledge in Sasuke and Naruto's abilities and would probably be the most efficient pair in taking Naruto and Sasuke down. Itachi and Kakashi have already worked together in their anbu days and are both great strategists in battle. Itachi's yata mirror would be able to stop any attack that could be thrown at him, while his totsuka blade could seal both of them.