Board Thread:Naruto Discussions/@comment-24165784-20151108230957/@comment-1872728-20151110130647

Kyle Ethan wrote: Even if Izanagi were to activate at the time it was set for, it would require the users soul as a medium to activate in terms of chakra etc... Well, Madara activated Izanagi after he died, and he didn't have a soul then. So my guess would be: Yes, the Izanagi can negate, but only twice (two eyes). Since to my knowledge, the RDS only seals the user's soul after the target's soul is sealed. When the Shinigami snatches the soul, and Izanagi is activated, the soul that was snatched will disappear, but the Shinigami will continue to snatch the now "revived" target's soul, until the target can no longer negate. This is of course, if Izanagi is activated before the soul is sealed, and only while being snatched.