Mito Uzumaki

was the wife of Hashirama Senju, the First Hokage, the grandmother of Tsunade, the Fifth Hokage, and was the first jinchūriki of the Nine-Tailed Demon Fox.

Background
The Uzumaki clan and the Senju clan, being distant relatives, had always had close ties. For this reason Mito married her distand cousin, Hashirama Senju, who would help found Konoha and become the village's First Hokage.

After Hashirama's defeat of Madara Uchiha at the great battle at the Valley of the End, and arresting control of the Nine-Tailed Demon Fox from him, Mito used her clan's unique fūinjutsu style, (from which the Four Symbols Sealing style would be derived from,) and sealed the beast within herself in order to keep the threat Nine Tails posed contained. Despite the seal's strength, it almost broke at some later point when Mito was going through childbirth.

Mito was the mother of at least one child, and the grandmother to both Tsunade and Nawaki. Mito would also go on to survive her husband, and then, later, her brother-in-law, living all the way into Hiruzen Sarutobi's reign as Hokage.

Towards the final years of Mito's life, it was decided that a new host for the Nine-Tails would need to be found. Kushina Uzumaki, one of Mito's kinsmen, was then selected for the role due to her special chakra, and was terrified by the idea. Mito comforted her and, before the transfer was performed, told Kushina that love was the only way to tame the Nine-Tails' hatred.

To this day, Mito is survived only by her granddaughter, Tsunade, her kinsman, Naruto Uzumaki, along with any other remaining members of the Uzumaki clan after the destruction of Uzushiogakure.

Appearance
Mito was shown to have worn an elaborate kimono. Her hair was seen tied up in buns similar to Tenten and a diamond mark on her forehead, similar to that of her granddaughter Tsunade. She also has what appears to be seal tags in her hair decals.

Abilities
Not much is known about her fighting skills but Kushina said she was a powerful kunoichi. She was proficient enough with fūinjutsu to seal the Nine-Tails within her and is remarked as having incredibly potent chakra capable of restraining the beast. Due to being a member of the Uzumaki clan, Mito had an exceptionally long lifespan.

Trivia

 * Mito was the first known Jinchūriki since the Sage of the Six Paths.

Quotes

 * (To Kushina)