Board Thread:Naruto Discussions/@comment-46702312-20200902014722/@comment-6769189-20200911063622

It was specifically explained that Sasuke's Susanoo can block I.T.'s light. It seems that Six Paths Power/6 Paths Chakra is what grants immunity to I.T.

The eyes dont have to be lined up to cast/counter genjutsu. Genjutsu takes control of the target's senses via the eyes. Not even the Sharingan can stop that, it just tips of the Sharingan user that there is a Genjutsu and can see the difference between real and fake.