Board Thread:Naruto Discussions/@comment-38071683-20191222083305/@comment-44860984-20200114150916

Everything would have changed. After learning about the Mangekyo blindness, sasuke would probably take itachi's eyes. Thus activating the kotoamatsukami (crow with Shisui's eye) on sasuke. This would mean, itachi would not break the edo tensei. Maybe Nagato and Itachi could have killed Naruto and Bee. And that would have been the end card for the show.

PS: The amaterasu might have killed Itachi(if it activates on contact with any sharingan). But this is a If.