Board Thread:Theories and Speculation/@comment-32369776-20170708034118/@comment-734582-20170716131815

Rage gtx wrote: Sorry for late response, but I don't remember at any point manga stating that clan no longer exists can you cite at least one occurrence, without it claim of whatever happened to Senju is baseless. Directly from the wiki: It isn't clear if the Senju still formally exist as a clan, as no living Konoha villagers are known to still bear the name. Konoha Hiden suggests that they are no longer active, as Kiba Inuzuka only recognises the name from history classes. They were THE most influential and powerful clan around. But in modern-day Konoha, no mention is made of them whatsoever as being alive. Even Tsunade, who is Hashirama's granddaughter, is never explicitly called Senju. This implies that they are no longer around. The Uchiha and Hyuga are mentioned as powerful clans in modern konoha, but the Senju are not mentioned.

So, by their absence despite previous priminence, it's safe to conclude they no longer exist.