Kaguya Ōtsutsuki

Princess was the first human able to use chakra and was the mother of the Sage of the Six Paths.

Background
Centuries before the founding of the hidden villages, during an era of wars between man, Kaguya decided that it was necessary for someone to attain god-like powers in order to stop the wars. For this reason, she consumed the forbidden fruit from the Shinju, gaining the ability to manipulate powerful chakra and allowing her to single-handedly put an end to all the wars that plagued the lands.

Some time afterward, Kaguya later gave birth to a son, who was the first person born with the ability to manipulate chakra. However, the Shinju, furious of Kaguya's actions, was determined to get its chakra back and thus the Ten-Tails was born. Her son would be the one to later seal the beast within himself and teach the world how to manipulate chakra, becoming revered as the Sage of the Six Paths.