Board Thread:Theories and Speculation/@comment-25643824-20170907153936/@comment-30323490-20170907162617

You can't really compare Kakashi and Nagato in this situation to begin with. Nagato's Uzumaki lineage allowed him to weild the rinnegan without drawbacks, while Kakashi had to cover his eye when not in battle. So, considering that Naruto and Hashirama come from clans with greater life force just like Nagato, and on top of that they are also reincarnations, they would also wield the rinnegan without drawbacks and most likely on a larger scale than Nagato.

Also @Crazylazyguy, even if Black Zetsu rewrote the stone tablet, i don't think that he was targeting an Uchiha necessary.It just happened that he found an easier way to manipulate Madara than Hashirama, thanks to the stone tablet that the Uchiha's worshiped so much.Madara bit a piece off of Hashirama and implanted it in himself, and so, after years, his rinnegan developed.And actually, Madara's actions imply that someone from the Uzumaki/Senju lineage would be more suited to wield a rinnegan, since Madara seek out Nagato (an Uzumaki) and not somebody from his own kin (an Uchiha). In reality, it is only required to have cells from both reincarnation of Asura and Indra in order to awaken the rinnegan, not to be necessary from one of the 3 lineages.