Board Thread:Boruto Discussions/@comment-33545035-20191020164526/@comment-43403813-20191027022836

Replying to something said earlier, to be fair, Sasuke was able to perceive "nano-sized" bugs in his fight with Deidara, and that was only with a pair of three-tomoe Sharingan. "Nano" literally means one-billionth of something.

Granted, I don't know the size difference between an amoeba, or a nano, or a microbe or whatever. But given the fact that Sasuke has both a Rinnegan and EMS, shouldn't he be able to see shrunk Isshiki, probably noticing the dense amount of chakra in Jigen. I don't see why Naruto wouldn't be able to sense Isshiki either.