Board Thread:Versus Debates/@comment-31201212-20170201043120/@comment-31201212-20170202005442

It takes one hand-seal to activate Tsunade's Strength of a Hundred Seal, and once it's open, she's physically impervious to anything Killer B can do in his Tailed Cloak form, not to mention her strength and speed is increased drastically. With Tsunade and the summons present, Jiraiya would definitely have enough time to enter Sage Mode.

Time is not a major factor here, it's whether or not Jiraiya and Tsunade can kill Killer B before Hachibi is released. If Hachibi is, then their only means of survival is to escape, which I believe they could.