Board Thread:Theories and Speculation/@comment-24901923-20170305163200

Eight Gates: Unlocks body's natural safety limits to greatly increase user's physical power at the cost of immense recoil, up to and including death.

Sage Mode: Greatly enhances the senses, bodily awareness, physical attributes, and jutsu of the user, with additional school-specific abilities. Extremely difficult to learn, and sustain in combat.

Chakra Enhanced Strength: Gathers large quantities of chakra in the hands/feet and discharges them at the time of impact to greatly increase striking power. Requires high chakra control and precision.

Strength of a Hundred: Creation Rebirth: Supercharges the body's regenerative processes to heal any non "instakill" wounds at the cost of the user's lifepsan.

Given that Might Guy was able to challenge Madara Uchiha as the 10 Tailed Host with his mastery of the Eight Gates, I started to explore what it might take for a shinobi in the Naruto-verse to genuinely "Punch out Cthulu", with the physical demi-gods of the Otsutsuki Clan(Kaguya/Jyuubi, Momoshiki, etc) being the local equivalent of Cthulu. The combination of the jutsu listed above is what I've been able to come up with so far without resorting to any kekkai genkai.

The combination of the Eight Gates and Sage Mode results in a great deal of synergy, albeit likely at the cost of further exasperating the latter's sustainability problem. The physical power granted by the Eight Gates would be amplified to an even higher extreme by Sage Mode, as well as the user's ability to control and apply it. At this point, a shinobi could likely threaten, defeat, and outright kill Jinchuriki!Madara by themselves, and challenge Kaguya. The addition of Chakra Enhanced Strength would further increase the already-monstrous force the "Eight Gates Sage" could unleash in a given blow, albeit to a even larger degree thanks to the use of Sage Chakra. I'm unsure of Chakra Enhanced Strength's compatibility with Frog Kata and the other Sage school techniques. Utilizing Strength of a Hundred: Creation Rebirth would not directly enhance the combat ability of the "Eight Gates Sage", but would allow them to trade part of their lifespan for increasing the time their body can sustain using the Eight Gates, with Sage Mode further increasing it's efficiency. 