Board Thread:Theories and Speculation/@comment-26636534-20170825214524/@comment-5085906-20170825224549

Actually, I think it was destroyed AFTER one of the wars, when some of the great nations banded together and obliterated them because they were afraid of their fuinjitsu capabilities.

Ninjaedit: I am wrong actually. It happened during a war. And according to @Seelentau's established timeline, it probably happened during the Second World War since that timeline dictates Kushina was born in the 15-20 year period of rest in between the First and Second World War. She moved to Konohagakure around the age of 9-10, perhaps..so, yeah Second.

And what does Nagato's parents dying during the Second War have anything to do with the destruction of Uzushiogakure? Actually, that only supports it, considering his father was apparently exiled in Amegakure.