Board Thread:Boruto Discussions/@comment-26956327-20160621154400/@comment-734582-20160625133313

Ravenlot 27 wrote: Hashirama was reputed as a "God of Shinobi" during his livetime and was considered the strongest shinobi alive, but still somehow died and surely not the natural way. Someone replaced his Sugar cubes with pure Botuline.

Really, considering the cirumstances, i'm 100% sure someone poisoned Hashirama with enough poison to murder a continent.