Board Thread:Versus Debates/@comment-30426414-20161228222316/@comment-25122992-20161229140529

No, this drawback was mentioned for the whole cursed seal practice. It was Sakon who said it, and he already developed CS2 back then. Also, in the part 1 VoTE fight, when CS2 Sasuke prepared to use his final Chidori, he felt the pain from CS, recalled Sakon's words and stated that it's already time to end this time, while noting that Naruto seemed to have a similar drawback from the Version 1 too (his left arm was paralysed, if you remember it). Also, Sasuke experienced the same pain when he was standing before the unconcious Naruto after the fight concluded.

I can't say it'd be easier for Itachi. Since Sasuke has an MS here, Itachi isn't able to outclass him with the marvelous MS techniques, since Sasuke almost the same techniques, and while he doesn't have Tsukuyomi, with MS, he's surely able to break out of it. Also, Sasuke has the edge in the chakra reserves. The only things Itachi can rely on are his tactical mind and Susanoo relics.