Board Thread:Theories and Speculation/@comment-36649908-20180820043133/@comment-6769189-20180926063527

Considering Hyuuga and Uzumaki/Senju have never been together without additional DNA there is no reason it cant create something new.

Much like how Hamura eventually unlocked the Tenseigan, which Kaguya never had. Its likely he developed this ability because he didnt have a Rinnegan/Rinnesharingan, allowing his Byakugan to change and evolve.

The series also has a precedent for mutations.
 * Kaguya's Rinnesharingan became Hagoromo's Rinnegan which became Indra's Sharingan which further mutated into the Mangekyou. Sasuke later got a Rinnegan that could work in tandem with his Sharingan and Mangekyou. It could even be argued that every Mangekyou is minor mutation as each pair has unique patterns and abilities.
 * Hamura inherited the Byakugan from Kaguya but his evolved into a Tenseigan and hers didnt. His descendants' Byakugan were unable to become Tenseigan without both bloodlines coming together in some way, so there is a mutation there.
 * Kaguya's Ash Bone is said to be the origin of Kimimaru's KG but it doesnt have some of the redonculous abilities Ash Bone does.

Its prefectly within reason that inprecedented combination of genes would push evolution in a different direction.