Board Thread:Naruto Discussions/@comment-24347194-20150211225344/@comment-5936871-20150406014931

Itachi wouldn't even be able to setup the Izanmai on Minato because he would have to make physical contact with him a few times in order to setup a sequence of events. Remember all he had to do and how much time it took to use it on Kabuto? By the time Itachi had finished setting it all up and preparing it he would have been killed by Minato already. Itachi would have to go on the defensive immediately and he would be incapable of putting Minato in a genjutsu because that requires eye contact and Minato isn't stupid enough to look into the eyes of a Uchiha prodigy known for his prowess in visual genjutsu with the Sharingan. Minato would rely on his speed to blitz Itachi in order to eventually land a killing blow however Itachi's Susanoo would be able to counter Minato's rasengan for sure. So it's really hard to say, but since we're talking about them both being at their strongest before they died, Itachi still has his disease, therefore Minato would wait until Itachi quickly ran out of chakra to use susanoo and then land a killing blow on him with a rasengan.