Board Thread:Theories and Speculation/@comment-26388300-20150523085628/@comment-25093611-20150529192530

A True Sage wrote: We literally see Tsunade lay a full-force punch directly to Orochimaru's face lol... and the dude got up. I don't think his body is weak, necessarily, I just don't think it's suited for senjutsu training due to his unnatural jutsu experiments. this could be very well possible, aftrall minato also said something like "im not really suited for sage mode" despite mastering it (like oro) ^_^

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i always thought he used some kind of jutsu, afterall he even survived 4-tail-kyuubi as if he was toying with him :)