Board Thread:Naruto Discussions/@comment-26431570-20190526171926/@comment-26636534-20190527185206

Bambusek wrote:

If I remember correctly, Hashirama and Mito got married before Madara left the village, so it is possible Mito was a mother before becoming jinchuuriki. That would explain why Tsunade has no whiskers despite being related to Mito.

But again, Kishimoto never really cared about it. Nice, common sense at work.