Board Thread:Versus Debates/@comment-9782468-20150612024335/@comment-26127155-20150614092907

Well I think Kakashi personally edges this battle, but it would be a very hard challenge

Kakashi
 * Kamui (could separate Tsunade into pieces which would be nearly impossible to recover)
 * Sharingan would allow him to keep up with her movement as well as giving him a genjutsu adavantage.
 * Shadow clone diversionary tactics in order to give himself enough time to land Kamui.

Tsunade
 * strength of 100 seals, makes Tsunade immortal for a LIMITED amount of time.
 * Katsuya is a very powerful summon but is more of a support character compared to the other 3-way deadlock summons.
 * Tsunade is a lot more stronger and has more stamina.

As long as Kakashi keeps the battle between med-long range combat (Tsuande's strength shouldn't be an issue, and he just needs to use his sharingan and shadow clones to bide himself enough time to land a direct Kamui).

Tsunade is a very strong kunoichi (strongest with Sakura, Mei, and Konan) and deserves the title of Sannin but she lacks the multitude of powerful summons that Jiraiya and Orochimaru have in order to swarm her opponents.