Body Pathway Derangement

This is a high-level form of medical ninjutsu that only Tsunade has been shown to have mastered. Tsunade creates an electric field by giving her chakra the properties of electricity. When she strikes a target with her hand, the electricity pours into their nervous system and rearranges their body's signals. Ordinarily, the brain sends electric signals to the body to control how it moves. But when under the influence of this technique, these signals will produce any movement other than what the brain intends. When used against most opponents, they will be unable to do something as simple as walking, much less continue fighting.

The target can partially overcome this technique if they manage to relearn the connection between their brain and their limbs, as Kabuto Yakushi demonstrates. However, this is not an easy feat and takes a high amount of concentration and intelligence.

Trivia

 * Because of how its entry in Tō no Sho is worded, it isn't clear if this qualifies as Lightning Release.
 * In Jump Ultimate Stars, Sakura uses this technique by charging chakra in her hand and thrusting the opponent with her palm, causing damage and leaving the target confused.