Board Thread:Naruto Discussions/@comment-25464204-20140925215818/@comment-18497248-20140925221053

1. All we know is he died in the first ninja war.

2. No idea, I never understood it in the first place.

3. Old age??

4. I don't believe so, others do.

5. She didn't, she only made them into Zetsus because she hates humanity, as Hagaromo recently explained.

6. What's there to know, they were originally one with the Senju but some branched off and created the Uzumaki.

I hope this helps somewhat.