Indra Ōtsutsuki

The Uchiha clan ancestor was one of two brothers born with the abilities of the Sage of the Six Paths. The older of the two, he was born with the Sage's "eyes": the powerful chakra and spiritual energy. He believed that power was the key to peace. When the Sage was on his deathbed, he selected the younger brother to carry on his dreams of peace for the ninja world. The older brother, believing he should have been chosen, fought his brother to try and claim what he felt he deserved. His descendants, the Uchiha clan, would continue this fight with the younger brother's descendants, the Senju clan.

Trivia

 * As the older brother was born with the "eyes" of the Sage of the Six Paths, it may be possible that these "eyes" evolved into the Sharingan.