Board Thread:Naruto Discussions/@comment-33156423-20170923231447/@comment-24319911-20171005144310

Returning to "descendants of Kaguya Ōtsutsuki", I think Kaguya Clan exist because of cross breed line of Hamura and Hagoromo descendants. Boruto and his Jōgan may be an example of what will happen when these two bloodlines come together again.

So maybe Shikotsumyaku happens when Hyūga clan (taijutsu) and Uchiha clan (madness) cross breed + a little good old Black Zetsu manipulation (knowledge about Kaguya)? :)