Board Thread:Theories and Speculation/@comment-26636534-20150927142502/@comment-734582-20150927215735

Curse of Hatred wrote: If it hits. Sure, but isn't that the point of any technique? Like i said, it's pretty much a one-hit-kill. It only needs to hit once. It doesn't need to hit reliably (I mean, if jutsu had to hit reliably then Naruto would've never won a fight), it just needs to hit once. Kabuto's up against two pretty damn powerful people, so i guess it's a matter of finding a combination of techniques that makes it hit. Kabuto can't become intangible, and with two people you could pretty much force him to chose between two deadly jutsu, e.g. Amaterasu or Totsuka. Two people can spam amaterasu (which, if it hits, would also destroy Kabuto), two pretty powerful Susanoo, both with a range of pretty powerful jutsu.

I think it would probably be a lengthy, epic fight, and it's one of my major annoyances that we never got to see the full length of it. It'll probably be close too, but i do believe that of all the possible outcomes, Itachi and Sasuke winning is close enough to a coin toss.