Board Thread:Theories and Speculation/@comment-27082825-20150116155842/@comment-26023629-20150123052723

Bricks work too. There's plenty of ways to frame the idea.

See, if Iwa really had genetic engineering on the level required to make something as complex as a kekkei tota, I think it would be very easy for them to simply clone one of their success stories, Onoki or Mu. Cloning is amongst the easiest possible things to do if you know how to mess with genes, after all, it's something we can do with people in the real world, and in the real world we don't even come close to the sort of bodily modifications Orichimaru is capaple of. Just a few Mu clones would easily recoup the losses garnered by their creation. By the way, I don't mean giving their abilities to someone else like Hashi and Yamato; I mean literally just tube-growing some identical Mus. If Kabuto can do it with a giant snake, I see no reason that the whole village of Iwa couldn't with a person.

As for the Kaguya thing, I'm thinking less in terms of real world genetics and more in terms of what Kishimoto has established about her role in the formation of many notable clans (and their respective kekkei genkai). While the Koga ninja scrolls were the inspiration, it's established that the breakdown of the Kaguya's Rinne Sharingan created lesser dojutsu. In the same vein, TSBs were described as "like a kekkei genkai or kekkei tota, but beyond either" and were compared to dust release in their function. That leads me to believe that the ability to make TSBs broke down into separate advanced natures over the generations in the same way the rinne sharingan separated into different, weaker dojutsu.

Also, Kishi already established that combining certain parts of Kaguya's DNA in people can awaken a "higher tier" of that ability- the rinnegan is formed from the combination of Indra and Asura's DNA, or their reincarnation's DNA, anyway.