Board Thread:Versus Debates/@comment-27418151-20160528023643/@comment-25122992-20160530094818

Well, since Madara himself implied that Kabuto "knew the secrets of his body", it's quite possible, although I'm not sure that he could create something akin to wood-supressing serum. If Kabuto had invented some countermeasure able to supress doujutsu powers (which are the main abilities of Madara), it stands to question why he didn't use it in the battle against Itachi/Sasuke.