Board Thread:Theories and Speculation/@comment-36649908-20180820043133/@comment-36649908-20180926031534

Actionmanrandell wrote: have you ever thought if this little thing called, a Mutation. the uzumaki and hyuga may have descended from kaguya but their DNA has changed so when the DNA's were united again it resulted in a new dojutsu

Well considering this is an ainme, we can't just apply real world logic/science to it unless they do. The naruto world has never mentioned anything like a mutation in someone's gene's or bloodline.

If genetics worked in naruto like it did in the real world then all of the major clans like the uchiha, hyuga, an so on would be full of deformed mentally challenged people because of all the inbreeding.

Also their DNA would be much weaker than the first generation of the clan, as they have no doubt been watered down since kaguya and hagoromo.

I read that to make a rinnegan you actually need the recombination of Indra and Ashura chakra along with senju and uchiha DNA. So the chakra itself matter, but putting it all back together again would just make the same thing. Just like Senju and Uchiha DNA combined together with Indra and Ashura DNA made the rinnegan--which it originally came from, and not something new. There are no mutation in that world