Board Thread:Theories and Speculation/@comment-34656247-20180531072459/@comment-33150793-20180602204414

The Tsukuyomi has only been used on two people. One was Kakashi, who at that point, is still unable to handle his eye like an Uchiha (a weakness he later overcomes) and one was Sasuke.

When we've shown that a stronger Tsukuyomi, IE: the Tsuki No Me, can be resisted by an alternative method, that casts Itachi's statement in doubt.

Hashirama's powerful chakra and ability have been shown when we see he can snap out of ET's binding whenever he feels like it at near full power. If nothing else, it casts it in strong doubt that Tsukuyomi can work on Hashirama without him resisting or breaking it.