Board Thread:Versus Debates/@comment-9782468-20150612024335/@comment-26104757-20150615020514

Tsunade is a very strong kunoichi (strongest with Sakura, Mei, and Konan) and deserves the title of Sannin but she lacks the multitude of powerful summons that Jiraiya and Orochimaru have in order to swarm her opponents.

Shikkotsu Forest only homes Katsuyu is general, it is dependent on how much chakra being used which will vary the size when she is summoned. It took Tsunade and Sakura with both Byakugō activated to summon 1/10 of Katsuyu, to imagine her full size would be extraordinary. And to that, Katsuyu's Slug Great Division grants her the ability to divide at will. I say this because Tsunade doesn't require more then one summon, when Katsuyu works in-conjunction with her Byakugō, and is able to use the Slug Great Division technique to swarm, and overwhelm her opponents and/or simultaneously healing/covering multiple people at the same time.

With that aside, having Kakashi serve as an Anbu captain, and Tsunade being renowned as one of Konoha's Legendary Sannin, I would have both Tsunade, and Kakashi stand fairly close together in weighing who would win in battle, but Tsunade would suffice as the lone victor with mid difficulty.

Tsunade has experience over him by two generations, I mean, she made history. Her chakra reserves out-lasts Kakashi's by long, and I'm not even convinced she'd have to activate her Byakugō to win. Kakashi and Tsunade would stand equal in intelligence, so the normal 'go-to' diversion attacks won't work. Tsunade's raw strength would do alot of collateral damage, and having Katsuyu at hand would even aid to her victory. Kakashi would put up a good fight, but he's no match for Tsunade.