Board Thread:Naruto Discussions/@comment-24757127-20140709042852/@comment-8839944-20140709181106

It is never stated what happened to the Senju... in the manga or otherwise. So far we can only bank on speculation and logical guessing.

And please. We know the majority of the Uzumaki were killed off. No intermarriage required. Kushina's generation was most likely the only real survivors left. But that still leaves Karin....who were her parents? What happened to them? Oh well....so many questions left unanswered.