Board Thread:Naruto Discussions/@comment-46448870-20200726053501/@comment-26636534-20200726124345

Doubt it. Her Byakugou seal was depleted during the pain arc. And there probably was not a lot of time between the pain arc and war arc for her Byakugou seal to be at max capacity. A logical assumption would be, given more time, Tsunade would have sealed away more chakra, and therefore, would be able to fight longer.

That, and age related Prime status. Her reflexes, chakra, stamina, agility etc were probably better when she was 30.