Board Thread:Theories and Speculation/@comment-34656247-20180531072459/@comment-5311048-20180604164313

In my opinion,

Hashirama would be effected by the affect on the Genjutsu, but, due to him being one of the most powerful Shinobi, I'd think he'd be able to withstand it and continue to fight, but would be greatly weakened until healed.

While yes he does have his regenerative ability, it does take time for that to heal completely. So Hashirama would be effected, but probably still be able to fight his opponent afterwards, but not in full strength.

Remember Hashirama still died in battle protecting the village and his comrade. So while he is extremely powerful, there would still be times where he'd be limited to using his strength.