Board Thread:Naruto Discussions/@comment-3965545-20160202201023/@comment-142748-20160202201619

Since Itachi had disappeared for quite a long time and he thought Danzo was going to betray the deal they made. Hell it wouldn't be surprising if Danzo didn't know his wearabouts since Itachi directly reported to Hiruzen in secret. So with Hiruzen dead, his protection over Sasuke lifted, Danzo was in prime position to eliminate Sasuke.