Kaguya Ōtsutsuki

Princess was the first human able to use chakra and was the mother of the Sage of the Six Paths.

Background
During the era of endless wars, Kaguya decided that it was necessary for someone to attain god-like powers in order to stop the war. For this reason, she consumed the fruit from the God Tree, gaining the ability to manipulate chakra as well as gaining god-like powers allowing her to single-handedly put an end to all the wars.

Kaguya would later give birth to a son, who was the first person born with the ability to manipulate chakra. However, the God Tree became furious by this and was determined to get its stolen chakra back, and thus became the Ten-Tails. Her son would be the one to later seal the beast within himself and teach the world how to manipulate chakra, becoming revered as the Sage of the Six Paths.