Board Thread:Boruto Discussions/@comment-25192437-20191112175648/@comment-4080775-20191113004610

Yes, and I dont see why that matters to people. Naruto has been using Kurama's chakra a lot more than any other Jinchuriki in the history of the Naruto series. He literally goes into the mode against every single threat he faces. That alone should be enough to warrant adverse reactions within his body. Bee doesn't use his Tailed Beast chakra absolutely nowhere near as much as Naruto does.

Its pretty much similar to a person developing an allergic reaction to something later in life when they were perfectly fine using said thing earlier in life.