Board Thread:Naruto Discussions/@comment-32685487-20180610182908/@comment-734582-20180613215626

FlatZone wrote: But I think Nagato is special among them all, which is why Madara chose him and which is why Nagato could wield both eyes with no drawbacks even as a kid. I think Madara simply used some sort of seal on the eyes that locked away their true power until he would be strong enough to awaken them. He subconsciously murdered shinobi with them, and when enraged he could summon the Gedo.

Alternatively, Obito was simply too greedy with the eyes and tried to use them on Nagato's level (unlike Nagato, he had access to pretty much all it's secrets), which is why the eyes reacted so strongly.