Board Thread:Naruto Discussions/@comment-27521865-20190624190722/@comment-6769189-20190630053831

It isnt a biological fact. What are you on? It was explained that the CoH was due to the Uchiha's intense love/loyalty, not because its some weird ass cancer adjacent.

The curse caused the Uchiha-Senju rivalry but the curse isnt dependant on the Uchiha-Senju conflict. An Uchiha can succumb to it without a Senju being involved.