Kāma

is a seal that serves as a compressed backup of an Ōtsutsuki clan member's biological data that they can embed in the body of a compatible recipient known as a. Over time, the Karma will gradually overwrite the vessel's genetic profile until they transform into a perfect Ōtsutsuki. Should the Ōtsutsuki be slain, their soul will migrate to one of their vessels and become anchored to the world of the living, and when the Karma completes will through their body, completely replacing them.

In the interim, the vessel can learn to activate the Karma and utilise a portion of the Ōtsutsuki's power and abilities, and if reincarnation has not yet been achieved, the soul of the slain Ōtsutsuki can even manifest and temporarily take control over their body.

Compatibility with an Ōtsutsuki is exceedingly rare and unpredictable, and if an individual is not a suitable recipient, the ritual will typically result in them suffering a fatal seizure. Occasionally, an unsuitable vessel will survive the ritual, however, producing a unique variant of the seal called the. Such individuals are unable to serve as a receptacle for the Ōtsutsuki's soul and thus cannot be used for the process of reincarnation, nor can use its absorption power nor space-time ninjutsu, but retain its other traits, gaining tremendous power and even being able to transform into a completely new Ōtsutsuki.

Appearance
Though the Karma superficially resembles a tattooed seal, it is actually a pyramid-shaped barb that is embedded in the vessel's body. Upon activation the visible marking will spread across the vessel's body, at times taking on different patterns depending on the abilities being used. Typically black, these markings may also shimmer and glow with a particular colour when activated (red in Kawaki's case and blue in Boruto's case), and when viewed up close appear to spread in blue patterns resembling microscopic circuitry. Karma may produce a variety of different patterns depending on the individual, where on their body it is embedded, and what abilities are being accessed. As its name implies, the White Karma is white in colour rather than black, and its markings may also shimmer and glow with a particular colour too when activated (grey in Code's case).

Isshiki Ōtsutsuki
Jigen: Isshiki embedded his Karma into Jigen's chin while parasitically fused with his brain, after being betrayed and nearly killed by Kaguya Ōtsutsuki. When activated, it spreads across his face and body in nearly symmetrical sunburst patterns. Progressing further, he sprouts a long horn identical to Isshiki's. This Karma served its purpose and vanished when Isshiki was forced to reincarnate through Jigen's body.

Kawaki: Upon realising that Jigen's body would not be able to sustain his chakra, Isshiki transferred his Karma into Kawaki's left palm through scientific experiments and a ritual conducted with the aid of Amado Sanzu. When activated, it spreads across the left side of his body, forming a pattern that almost perfectly mirrors Boruto's, extending up to his left eye, and then glows red. Progressing further, he sprouts a short horn resembling Isshiki's. He lost this Karma when Isshiki resurrected via Jigen's body, but later it was secretly reapplied by Amado while restoring Kawaki's right arm, for it to function purely as a weapon after Isshiki's soul vanished. Isshiki's Karma in Kawaki was estimated to be 80% extracted prior to its removal. By the first battle against Code, the Karma was advanced enough let Kawaki access Isshiki's raw power and various abilities, including Isshiki's dōjutsu.

Code: Among Isshiki's previous failed candidates was Code, the only failed vessel of the children Jigen gathered that survived the ritual. As such he bears a White karma, which is located on his left palm. As Code is not a vessel, his karma did not vanish upon Isshiki's revival into Jigen's body, and before his soul expired, Isshiki entrusted Code with carrying on the Ōtsutsuki's will and bade him to become a complete Ōtsutsuki by sacrificing either Boruto or Kawaki to Ten-Tails and feeding upon the resulting God Tree's chakra fruit. When activated, it spreads grey (light blue in the anime) markings along the left side of its body forming a pattern that almost mirrors Jigen's, extending to the left eye.

Momoshiki Ōtsutsuki
Boruto Uzumaki: Momoshiki embedded his Karma into Boruto's right palm as the boy dealt a fatal blow to him using a Parent and Child Rasengan. When activated, it spreads across the right side of his body, forming angular and curving geometric patterns, extending up to his right eye, and then glows blue. Progressing further, he sprouts a horn similar to Momoshiki's and his right eye turns into a Byakugan. Upon facing Code, Momoshiki's Karma in Boruto had reached 82% extracted. Following Boruto's attempted suicide, Momoshiki used the remaining 18% to revive Boruto to save his soul, cancelling his resurrection through Boruto.

Abilities
When activated, Karma significantly enhances the user's physical speed, strength, and jutsu power, and allows them to absorb chakra and chakra-based attacks like ninjutsu. Karma can also be used as a medium for Space-Time Ninjutsu, transforming the mark on their palm into a symbol resembling their horn pattern and opening a rift to any location, including foreign dimensions. This ability seems to be rather advanced as only Jigen was able to use it by himself, Boruto and Kawaki's needing to cooperate to use it instead at first.

If one properly draws on their Karma, they can overlay the accumulated with their mind and body, instantly becoming a seasoned fighter. According to Code, this is the true essence of Karma and grants the user an exponential increase in battle power, well beyond that conferred by the enhanced physical abilities alone. When accessing this power, ring markings seem to appear around the user's fingers.

With enough experience, the user can progress the Karma to a more powerful state, gaining access to the Ōtsutsuki's unique powers, including their Shinjutsu. In this state the user will begin to undergo a physical transformation, growing horns and awakening their Dōjutsu, generally limited to a single eye. According to Kawaki, knowing that he and Isshiki were alike helped him realise that he could do anything Isshiki was capable of, allowing him to quickly intuit how his abilities worked. Boruto was initially unable to enter this state without Momoshiki taking over his consciousness, but was able to partially access it while affected by Amado's Byakugan-suppressing medication.

Resonance
Boruto's and Kawaki's Karma exhibit when in close proximity. Isshiki and Amado theorised that it was this resonance that allowed both Kawaki's and Boruto's Karma to mature more rapidly than expected. Although Jigen is able to synchronise with Kawaki's Karma to open a space-time rift, no such resonance exist between the two of them as Kawaki did not experience the sudden growth until his contact with Boruto. This resonance also often caused Boruto's Karma to activate involuntarily when Kawaki activated his own.

Manifestation
Under certain circumstances the soul of a deceased Ōtsutsuki anchored to a vessel can possess the vessel's body, using the Karma to wield the full extent of their power through the vessel. This seems to only be possible after a great deal of time, and typically only occurs when the vessel's chakra has been depleted to the point that they lose consciousness. In order to maintain control in such instances they must attempt to minimise the amount of chakra they absorb to prevent the vessel from awakening. Momoshiki was also able to force aside Boruto's consciousness while he was debilitated by Amado's Byakugan-suppressing medication, allowing him to temporarily manifest without the drawback of limited chakra.

Resurrection
Over time, the vessel's own genetic information will be completely overwritten by the Ōtsutsuki biological data accumulated in the Karma, at which point the Karma will disappear and the Ōtsutsuki will resurrect, taking over the vessel's body and erasing their personality. This is the true purpose of Karma, and allows the Ōtsutsuki to transcend death. Even if the vessel's body dies and is severely damaged and/or not fully compatible with the Ōtsutsuki, or the Ōtsutsuki is only partially manifested, so long as it exists and still bears Karma, it will remain viable for the Ōtsutsuki to resurrect through, in which any damage it has suffered will be healed. Despite being reformed virtually identical to how they were in their previous body, the Ōtsutsuki also retains all the memories, skills and knowledge from the vessel.

With the aid of technology developed by Amado Sanzu, Isshiki was able to transfer his Karma to other individuals using Jigen as an intermediary, albeit with a low rate of success, as of fifteen known test subjects, thirteen are confirmed to have died, with Kawaki the only known successful recipient. Amado wants Kawaki to use a similar method to embed a Karma containing the biological data of his daughter, Akebi Sanzu, into a clone of her in order to facilitate her resurrection.

Amado noted that there is no known way of removing a Karma from a vessel, nor to stop its takeover, aside from killing the vessel before the resurrection process completes itself; even the very Ōtsutsuki who placed the seal onto the vessel cannot control the automatic transfer. However, the Karma's final process of resurrection will not occur so long as the Ōtsutsuki in question is still alive, hence Isshiki was not reborn through Jigen's body despite the Karma already having extracted all the data into Jigen's body. At the same time, a non-suitable vessel can be used to perform an imperfect resurrection of the Ōtsutsuki. Upon being resurrected, should there be any other Karma implanted by the same Ōtsutsuki, those additional Karma will simultaneously be erased. Amado speculates this is a safety feature to prevent duplicate incarnations of the same Ōtsutsuki. However, despite the Karma's erasure, any Ōtsutsuki data that was already extracted will remain so. Also, White Karma will not disappear if an Ōtsutsuki resurrects via a complete Karma. Alternatively, the soul of the Ōtsutsuki can alter the remaining programming of their Karma to rebuild the vessel's body once, saving their soul but cancelling the resurrection.

Though untested, Kawaki hypothesises that he and Boruto may be able to produce Karma of their own, as they have each already had in excess of 80% of their body overwritten by Ōtsutsuki genetic data. If proven true this, could potentially allow Boruto to survive Momoshiki's reincarnation by subsequently reincarnating through a vessel of his own. Kawaki also theorises that Code, bearer of a White Karma, would be an ideal candidate for Boruto to use as a vessel, as Code proved himself being compatible to survive the process while not being anyone's vessel. Amado claims to be able to restore Kawaki's Karma, which would restore his access to the Ōtsutsuki powers in his body without the drawback of being taken over by Isshiki, as his soul has vanished.

Resuscitation
As the Karma also acts as an anchor for the Ōtsutsuki brander's soul to remain in the living realm, should the vessel sustain mortal injuries before the Ōtsutsuki's genetic data finishes extracting, they can choose to rewrite the remaining portion of the data to match that of their vessel and use it to repair their damaged cells and tissues, resuscitating them. As this requires sacrificing a percentage of the compressed data in their Karma, it makes it impossible for them to fully overwrite the cells of their vessel, and thus unable to complete their resurrection. However, Amado believes it remains possible for the Ōtsutsuki to emerge from time-to-time.

Drawbacks
Imparting a Karma onto a candidate vessel requires a huge amount of energy to do so; when Isshiki was fatally injured by Kaguya, he did not have enough strength to apply one to Jigen at the time. When applying a Karma normally, it seems to have no detrimental effects on the potential vessel, whether they are compatible or not, as neither Jigen nor Boruto suffer any negative effects nor any apparent pain. However, when Isshiki attempted to place another one while inhabiting Jigen, he and Amado utilised a seemingly different method that involved scientific aid, in which Isshiki would activate the seal from Jigen, and spread it to a recipient, causing them intense pain and, if incompatible, the recipient would most likely die, as thirteen children died this way. It is also possible that a failure be instead be gifted the White Karma, granting them the pure power of an Ōtsutsuki but not as a receptacle for the soul.

As Amado noted, the most important factor of applying Karma is the selection of the vessel; if an Ōtsutsuki uses an inadequate vessel for a revival, the body will be unable to handle the enormous chakra, and most likely die within a couple of days. Compatibility seems to be rare, as out of the fifteen children Isshiki attempted, Kawaki is the sole success, and Isshiki himself noted how Boruto's affinity with Momoshiki's Karma to be uncommon. Placing a Karma onto a clone is ineffective, as the mark will vanish and will not transfer back to the original.

Once the Karma is applied, its process of spreading the biological data into the vessel and the final resurrection initiates automatically, in which not even the caster can control it. When an Ōtsutsuki resurrects, this also causes all Karma currently existing on other vessels to disappear. This leaves the Ōtsutsuki vulnerable to a permanent death as there is no other vessels to anchor their soul in the living realm and ultimately extinguished, unless they can apply another Karma, especially if forced by circumstance to resurrect in an imperfect vessel.

Amado created a drug that weakens the Byakugan. He originally hoped to use it to weaken Isshiki, and theorises that this drug can stall Momoshiki from reincarnating through Boruto, as the Byakugan originates from the Ōtsutsuki, and weakening the kekkei genkai may slow the Karma that is transforming Boruto's cells. Untested possibilities led Amado believe the drug may require constant intake, that deteriorating eyesight and even death may result, and he warned that Naruto must not allow Hinata nor Himawari take it.

An individual who has been given Karma is viable to serve as a sacrifice for Ten-Tails, as they technically become Ōtsutsuki. It remains dependent on how much of the data is extracted onto the body, as Momoshiki determined that Kawaki was viable due to having 80% of the process completed. However, using such a vessel as a sacrifice will result in the tailed beast blooming into a God Tree of inferior size and a lower quality chakra fruit, as they are not completely Ōtsutsuki. Similarly, even if the data has been fully extracted but the vessel has yet to be reborn as Ōtsutsuki, if said vessel is incompatible with the Karma to begin with, this will also result in the God Tree's reduced size and ability to produce a fruit.

Using Karma in battle could prove taxing for less skilled users, even more so when they are already weakened, as Kawaki quickly collapsed after using it against Garō as he was already injured from defeating Kara's robots while Boruto was left so badly weakened after using it for the first time that he collapsed and had to be helped to return to Konoha. Additionally, activating it seems to cause a not sufficiently experienced user some pain, as Boruto expressed pain whenever he activates Karma. Jigen doesn't seem to suffer these weaknesses as he is much more capable at using them than either Boruto or Kawaki, as he never showed any reaction when activating Karma and using it in his prolonged battle with Naruto and Sasuke had no effect on him. However, one known weakness of the seal that even Jigen seems to suffer from is that incomplete vessels could breakdown from channelling Karma's full power, as after overpowering Naruto and Sasuke, the blackened section of his body cracked and he even cried soon afterwards and was forced to retreat back to be treated by Amado.

Karma can only absorb chakra-based substances, hence the wielder is vulnerable to non-chakra matter and energy such as viruses and natural flames. Furthermore, if a chakra-based construct is composited with enough non-chakra matter, Karma cannot absorb it.

Trivia

 * Though its furigana reading indicates the pronunciation, its kanji spelling is given as , a Japanese tool resembling a wedge or linchpin, and its full appearance when not embedded in a host's body has a similar appearance and function.
 * "Karma" means "wish", "desire", or "longing" in Hindu literature, and in Japanese it is also an uncommon way to write "karma". The latter is used as its official translation in Western media.
 * Sarada Uchiha has theorised, due to their similar appearance, that the Strength of a Hundred Seal may be related to it.
 * Amado compared the Karma's function to a sugar cube placed into a cup of coffee: both would slowly spread throughout their vessels, and upon completion, both would dissolve and disappear.
 * Any Ōtsutsuki who intends to become a sacrifice for the Ten-Tails to bloom into a God Tree utilises Karma to prepare a vessel beforehand, for their revival later on.
 * At 80% of data extraction in a vessel from a Karma, Momoshiki believes this is sufficient to make the target a sacrifice for the Ten-Tails.
 * In the anime, Isshiki had also attempted to apply the Karma on adults. According to Garō, a chance of survival comes at a cost, as he himself was chosen and survived, but at the cost of his right arm. However, Garō did not gain a White Karma.
 * In the anime, the first time Momoshiki took over Boruto, he spoke in a mix of his and Boruto's voice. The second time, he spoke only in his voice, Boruto's voice only being heard when he began to take back control of his body.
 * When Momoshiki used the Shadow Clone Technique through his vessel, his Karma applied to his clone, but when Boruto used the technique Karma didn't apply to his clones.
 * After Boruto broke his horn in his second possession by Momoshiki, it became smaller than before in the third.