Board Thread:Naruto Discussions/@comment-1512913-20170417105433/@comment-734582-20170417180821

Kakashisologod1 wrote: @Elvernora yes izuna and itachi would use it better than everyone else(other than true rinnegan owners)duo to them being half way to gaining rinnegan(being uchihas). Only transmigrants possess half the requirements of the Rinnegan. Regular Uchiha and regular Senju can't awaken it. By the blood-relation argument they're much better at it than someone not from those clans, but they aren't halfway towards a rinnegan.

Ravenlot 27 wrote: Well, I think that Itachi/Izuna would be still at a disadvantage in wielding Rinnegan compared to even Obito. Let's put it simple: these two have only a regular Uchiha chakra, not Indra's chakra (because they aren't his reincarnates). Although Obito possessed a similar regular chakra, he had an addition of Hashi's artificial body, i.e. a source of Asura's chakra. I admit that the eyes' previous homage by Itachi/Izuna could probably make their adjustment to the Rinnegan easier, yet chakra-wise, they have neither Indra's nor Asura's chakra or DNA traits, while it seems that only people with these traits should be more prone to the Rinnegan use. That's an interesting point, hadn't considered that. Yea it's definitely an interesting idea: does being a blood relative count more or less than being a transmigrant?

That being said, Izuna is a blood relative of Madara, who is a transmigrant. So while Izuna doesn't have that power, he still is compatible with Madara's chakra, and logically should be even when Madara transforms it to Six paths chakra. So Izuna isn't entirely a regular shinobi in this.