Board Thread:Naruto Discussions/@comment-24757127-20140709042852/@comment-24757127-20140709133010

Elvonora: You are right. Before posting this I read the Senju Clan page and the ending paragraphs for it just meander off and never says what happened to them. It talked about founding Konoha with the Uchiha, 1st, 2nd, 5th Hokage were/are Senju, 3rd student of senju, 4th student of a student of a Senju. Then talks about maybe there are more Senju or Tsunade is the last one.

There is no way a clan like the Senju would just "retire" from shinobi life. Unlike the Uchiha, they didn't have many enemies that we know of.