Board Thread:Versus Debates/@comment-29965012-20161221055011/@comment-26104757-20161227101030

Kakashi is too reliant on his Sharingan, without it, he cannot defeat Tsunade.

Despite his strategical mind, battle footing and listed Ninjutsu; Kakashi does not possess any metaphysical attacks that'll apply lethality in support toward a win. His greatest asset during a one on one fight is definitely the way he thinks, seeing through others form of combat and using that to find openings, but with Tsunade, that won't work. She is a aggressive fighter, but experienced, and believes advantage favours those who strike first. Kakashi will be overwhelmed from the beginning of the fight, and with no Sharingan, he loses the security of addressing people in close-quarters as well as making preparations to follow through with counterattacks. But as we've seen, he doesn't have anything that could be deadly at long range. Tsunade is too much for him when she works on a collateral scale, something Kakashi can no longer accommodate. He'd lose.

With middled difficulty, I believe Tsunade would win. The odds are against Kakashi, especially as Hokage. He is too weak.