Board Thread:Boruto Discussions/@comment-36351381-20180731025641/@comment-1872728-20180805135528

Jason of the Mangekyou wrote: that one of her parent was an uzumaki o.O..Guess i missed it ;_; Tsunade's grandmother is an Uzumaki (Mito), not one of her parents. One of Tsunade's parents is half Senju and half Uzumaki, since this person is the child of Hashi and Mito.