Board Thread:Versus Debates/@comment-26104757-20160511101338/@comment-2245550-20160512034911

While Itachi and Kisame are a very deadly team, Pain can still beat them. The Preta Path can destroy Kisame and Itachi's Susanoo, since Susanoo is most likely purely chakra in its form. Konan can provide backup to stall Itachi whilst Kisame is being sucked dry, and then Pain can finish off Itachi quite easily.

Itachi is a very dangerous foe, I'll admit that much. He's probably gonna knock down one or two Pains, but I'm pretty sure he's still gonna lose, considering he's only got the Mangekyo Sharingan and Pain possesses the Rinnegan.