Second Shinobi World War

The was the second of three great wars involving the majority of the shinobi villages and countries. Not much is known about the politics of this era, but there were known conflicts between Konohagakure, led by the Third Hokage, Sunagakure, likely led by the Third Kazekage, Amegakure, led by Salamander Hanzō, and Iwagakure, presumably led by a Tsuchikage. The majority of the fighting seems to have taken place in minor countries like Amegakure, leaving them devastated. The eventual outcome of the war seems to have been in favor of Konoha. It was also during this conflict that the Sky Country emerged to challenge the Five Shinobi Nations, only to be destroyed, as revealed in the second Naruto: Shippuden Movie, in which the Sky Ninja's descendants re-emerged to attack Konoha.

As with all wars, the Second Great Shinobi World War brought forth many heroes and took even more lives. It was during this war the legendary Sannin rose to fame and received their nickname from Hanzō during a skirmish with Amegakure. Tsunade in particular became famous as the world's greatest medical-nin while successfully countering all of Chiyo's poisons. It was also likely the war where Sakumo Hatake made his name as Konoha's White Fang.

On the other side, it was the war where Tsunade lost her younger brother Nawaki and her lover Dan, leaving her with an extreme case of hæmophobia. It was possibly the war that took the lives of Sasori's parents, an event that eventually led him to desert his village and join Akatsuki. The Ame Orphans lost their parents during the war, so Jiraiya took care of them for a while, claiming it was the least he could do. One of the orphans, Nagato, would later create Akatsuki because of his experiences from the war.