Board Thread:Theories and Speculation/@comment-34656247-20180531072459/@comment-25607614-20180614071010

It's highly possible that Hashirama would have some sort of defenses in place for genjutsu, especially of an ocular variety, since even if he didn't deal with Tsukuyomi, he would have to deal with Genjutsu Sharingan. To counter Tsukuyomi though, he would need to have proactive defenses.

If he got snagged by it, he's not getting out of it, pretty much nobody is. Think about it from the outside, looking in. All you would see is Itachi look at Hashirama, and he would stood there for a sec and fall over (paralyzed or dead). That would be the real amount of time that he had to counter the jutsu. Tsukuyomi doesn't distort real time, it just really twists a person's perception.