Board Thread:Versus Debates/@comment-26104757-20170303072554/@comment-26104757-20170305044654

What can Itachi do in base to harm them?

Nothing.

How long can he use MS?

5-10 minutes.

How ill is he?

Partially blind, low stamina and, possibly, die as a result of using his MS even further.

Itachi's Amaterasu is well-known, enough for another person from a different village to know what it is. Tsunade, at least, should too. He'll need to land Amaterasu on the female duo very early in the fight to win, but being blind, honestly, is not a likely chance. A direct line of attack can be compromised because of that, like setting a large area ablaze, but that's not enough to ensure Tsunade and Mei's death. Amaterasu and Susanoo seem to be the only way to kill them, but given his health and the people he is going up against, I'm not convinced he can.

20/100 Itachi wins.

80/100 Tsunade and Mei wins.