Board Thread:Versus Debates/@comment-26998824-20151210004253/@comment-5547501-20151215134621

I'd say it comes down to whether Tobirama can mark Itachi without getting caught in genjutsu.

Due to his low chakra reserves, I doubt Itachi would pull out Susano'o immediately, allowing Tobirama a chance to fight properly. I think that with FTG, Tobirama can dodge Amaterasu, due to the near instant movement speed and his good sensory abilities (the Raikage did it with his lightning armour, and he was slower than Minato). He can also equal any water or fire style jutsus and I believe he can hold his own, if not overpower Itachi in hand-to-hand. The only problem Tobirama wouldn't overcome is genjutsu.

If Itachi captures Tobirama in a genjutsu, the fight is over, but if Tobirama can get in close and mark him, then a simple FTG slash will finish Itachi. If he uses Susano'o later on, all Tobirama has to do is teleport inside it and it would be an easy win. Due to Itachi's skill with genjutsu, I would probably say the Uchiha would win 6 times out of 10.