Board Thread:Naruto Discussions/@comment-46974839-20200924181420/@comment-46974447-20200928002054

Seeing as how Tsunade was stabbed in the chest, and the heart is centered (though favoring the left slightly) I don't think it matters much. She still walked it off as if it was nothing, really. The heart and brain aren't the sole creators of chakra, and even if they were, as long as one remains at the least they'd be more than fine. The jutsu is literally known for making it's users unkillable (albeit with the minor drawback of it shortening your total life span, lmao).