Board Thread:Theories and Speculation/@comment-25643824-20170907153936/@comment-734582-20170907161850

Crazylazyguy wrote: Black Zetsu was specifically targeting the Uchiha for such a person and not the Senju. He actually wasn't. He approached both transmigrants for the Rinnegan, although the Uchiha were easier to manipulate into a feud.

Ninjachris wrote: My question is would a sharingan/rinnegan transplant in either naruto or hashirama (both being transmigrants) have the same debilitating effect on them as it did on kakashi and negato. Almost certainly not. Even if the debilitating effect would be present, their strong chakra and lifeforce would make them notice it a lot less.

It's not clear what a Rinnegan would do to a transmigrant, whether it would unlock their own six paths power.