Board Thread:Versus Debates/@comment-3523655-20180826020421/@comment-5085906-20180826133325

Kakashi was nearing 30 when he became Hokage so he should be in his early 40s in your scenario. He could win against Danzo if the latter employed that inbred dumbass strategy he used against Sasuke, where he tested Sasuke's Susanoo durability with a kunai and opted to waste a Sharingan by using Izanagi against some shuriken instead of dodging them or deflecting them.

As for the additional matchups, Kakashi loses all of them, but may actually stand a chance against Tsunade and old Hiruzen.