Mikoto Uchiha

was the mother of Itachi Uchiha and Sasuke Uchiha and the wife of Fugaku Uchiha. While she was alive, she seemed to like Sasuke better where her husband seemed to prefer Itachi. She was a very good mother, seeing as how Sasuke was able to talk to her better than his father. At one point, in order to cheer Sasuke up, she says that when she and Fugaku are alone Sasuke is all he talks about. Although she was Itachi's mother, she did have some suspicion about Itachi and knew that something was up. She was found dead with her husband during the Uchiha Clan Massacre, killed by Itachi.

Trivia

 * In the Viz Media translation of Volume 25, in the character introduction, instead of the katakana for "Mikoto," they show the characters for "Sasuke's Mother."
 * It is safe to say that Itachi and Sasuke get most of their looks from their mother rather than their father.
 * Between the both of them, Sasuke looks more like his mother than his brother.

Quotes

– (To young Sasuke) "Your brother is your brother. You are you. Father's always concerned about both of you." To Sasuke after he disagrees. "That's not it...Father is the rerestative of the whole clan...if the clan is in a bad position, he must protect it. Itachi is the older of the two of you...the job of looking after the clan must be left to him. Father is the supervisor of that job, so...that is probably why he pays more attention to your brother." – (To cheer Sasuke up) "But, the conversations in here alone...when he talks to me, your father only talks about you...And, because of that, he's always awkward with you." – (As Mikoto is bandaging her younger son.)"Geez. You should rest your body properly at least on your day of from the Academy. You don't have to push yourself too hard. To reassure Sasuke. ...Times have changed since then...and also, that boy, is special."