Board Thread:Naruto Discussions/@comment-28433996-20160511122527/@comment-34522152-20180130054911

Actually the Uzumaki clan were all Murdered dew to their feared Sealing Jutsu's. So technically the didn't just poof out of existence. When Kushina was academy age, Uzushiogakure (Hidden Eddy Village) Was destroyed and the remaining spread out.