Board Thread:Boruto Discussions/@comment-35173748-20180401150813/@comment-30323490-20180401151821

Considering that both Boruto and Kawaki posses that Otsutsuki "curse mark", my guess it that the Otsutsukis will play a major role in the story, and possibly be responsible for Naruto's presumable defeat. And yes, against an Otsutsuki, Mitsuki and Sarada would be easily taken down.