Board Thread:Versus Debates/@comment-27233105-20160130092635/@comment-27233105-20160217080043

That's true, but Tsukuyomi seems to be specifically designed to inflict pain. One reaction an Edo might have coming out of Tsukuyomi is disorientation, but I don't see any other physical damage being done to the Edo body.

I could speculate that Itachi could cause his victim to suffer from catatonia, to which I guess even Edo would be susceptible, but we haven't seen Tsukuyomi affect anyone in a such a way.