Board Thread:Versus Debates/@comment-31568508-20170323180643/@comment-27924662-20170325193658

Madara would lose badly here especially given its EMS, Itachi Himself has the capability to defeat madara as EMS alone. And With shisui it would done and busted especially given the two are known to have history and would make quite a team, I would further venture to say this is one of the best team in The Narutoverse. Plus I would also like to point out that Tsukuyomi and kotoamatsukami are jutsu of almost similar caliber. Especially in case of Tsukuyomi the jutsu can be only broken by "near family" or the sibling (like How sasuke broke a toned down version of it). Madara can't break this jutsu. Even if Madara brings in Kurama either of the uchihas can break the genjutsu control and the 'pawn' could be turned against madara. And since its EMS Madara can't use 25 Susanoo trick to overwhelm the two uchihas since his own chakra reserve isn't high enough.