Board Thread:Boruto Discussions/@comment-33584477-20171106221739/@comment-734582-20171107084238

Plecotus wrote: Given that all of the main descendant clans became citizens of the Hidden Leaf, it's not that much of a strech to assume that Sasuke and Naruto are in fact their direct descendants. Yes.

However, it seems logical that the Uchiha and Senju clans rarely interbred, so whatever blood relation Naruto and Sasuke have is extremely weak.