Missing-nin

are ninja who left their village, often because they have committed criminal acts. Their from that point further try to track them down and eliminate them. Kirigakure has a special hunter-nin taskforce whose only objective is killing traitorous ninja. The ninja organization Akatsuki is composed of ten S-class missing-nin. Most of the missing-nin throughout the series are antagonists.

From Konohagakure

 * Orochimaru (created Otogakure; presumed deceased)
 * Sasuke Uchiha (joined Orochimaru)
 * Itachi Uchiha (joined Akatsuki; deceased)
 * Kabuto Yakushi (joined Orochimaru)
 * Yoroi Akado (joined Orochimaru)
 * Misumi Tsurugi (joined Orochimaru)
 * Madara Uchiha (created Akatsuki)
 * Aoi Rokusho (joined Amegakure)

From Kirigakure

 * Zabuza Momochi (became an assassin-for-hire; deceased)
 * Demon Brothers - Gouzu and Meizu (joined Zabuza; presumed incarcerated)
 * Kisame Hoshigaki (joined Akatsuki; deceased)
 * Raiga Kurosuki (deceased)

From Amegakure

 * Suien (deceased)
 * Hisame
 * Kirisame
 * Murasame

To Akatsuki

 * Zetsu
 * Sasori (from Sunagakure; deceased)
 * Deidara (from Iwagakure; deceased)
 * Kakuzu (from Takigakure; deceased)
 * Hidan (from Yugakure; presumed deceased)