Nine-Tailed Demon Fox's Attack

Twelve years before the start of the series, after the end of the Third Great Shinobi World War, the Nine-Tailed Demon Fox attacked the village of Konohagakure.

The attack coincided with Kushina Uzumaki, the second jinchuriki of the Nine-Tails Demon Fox, giving birth to Naruto. It was mentioned that the jinchuriki's seal was at its weakest when giving birth, thus, it was carried out in secret, with Biwako Sarutobi, the Third Hokage's wife, as her midwife, a few ANBU as security, and with Minato keeping the Four Symbols Seal holding the Nine-Tails secure. The location was eventually tracked by a man in a mask, who resemblesMadara Uchiha, killing the ANBU and Biwako, and holding the newborn Naruto hostage, ordering Minato to walk away from Kushina. Presumptively, it was at this moment that he released the Nine-Tails to wreak havoc in Konoha.

Nobody was able to stop the Nine-Tails until Minato Namikaze, the Fourth Hokage, arrived to apply the seal on the Nine-Tails and sealed the Yin portion of the Nine-Tails chakra into his newborn son, Naruto Uzumaki while keeping the Yang portion within the Demon God. Whether Kushina died during the release of the Nine-Tails or when it was being sealed into Naruto (as she seemingly gave her chakra and part of her soul, together with Minato's, in the process of resealing the Nine-Tails within their son)is not yet known.

The village suffered heavy casualties during the attack, such that few of the villagers would forgive Naruto (who they viewed as the fox) for its actions.

Though the Nine-Tails had attacked many settlements regularly throughout history for no apparent reason, Jiraiya, Minato Namikaze, and Itachi Uchiha speculate that Madara Uchiha was behind the attack on Konoha. Madara denies this and attributes its rampage as a natural occurence: however, Minato claims to have fought him on the night of the attack.

As the Uchiha clan's Sharingan is able control the Nine-Tails, the elders of the village suspected them of being responsible of unleashing the attack. It was this spite that led them to attempt a rebellion, which ended with their mass assassination before it could happen.

In the anime, the Nine-Tails is revealed to have left behind large amounts of its chakra during the attack that, when gathered by Kazuma, allowing him to turn Sora into a pseudo-jinchūriki.