Board Thread:Versus Debates/@comment-9782468-20150612024335/@comment-26104757-20150616002041

JOA20 wrote: Tsunade wins in power, Kakashi in speed and variability. If we're talking about Double Mangekyō Kakashi, it's a piece of cake for the copy ninja. One Mangekyō might barely be enough to chop the Sannin's head off. Apart from Kamui and Susanoo, Kakashi has no jutsu which can truly harm Tsunade, since she got the Byakugō and all.

Even so, Kakashi would have to land the attack carefully, and precisely. I'd expect he'd use an advanced diversion to pin point Tsunade, but Kakashi run's the risk of Tsunade's fist colliding into him. One wrong move, and he's done for.