Board Thread:Boruto Discussions/@comment-31700161-20170610121821/@comment-734582-20170611120841

Starscream1998 wrote: Chapter 78, page 13

Or maybe you should actually re-read the Manga seeing as you obviously haven't payed enough attention. Kakashi IS right though: The Uchiha's origins do lie with the Hyuga. The Hyuga seem to be the closest connected to the otsutsuki so far, since every otsutsuki we've seen has Byakugan (but not all have Sharingan or rinnegan). Even so, the eyes share a common ancestor in Kaguya.

Also, the rinnegan IS a mutation. Not of the Sharingan as Kakashi thought, but of the Rinne Sharingan.