Board Thread:Versus Debates/@comment-28731007-20160627160729/@comment-1751565-20160819123652

Tsunade wins. She is able to shatter Madara's Susano'o (which i rate to be higher defense than Kimimaro's bones honestly), she is capable enough in Taijutsu to eventually strike him, plus she has Automatic healing...Was bisected in half by a Huge Wood Style and still abe to remain alive for hours after, do Summoning and heal four other mortally wounded people on just Dan's Transferred Chakra - powered 100 Healings Seal. I havent even mentioned Katsuyu's capacities as yet...

She being the Most powerful Medic (able to discern someone's illness by a mere glance) also gives her an edge, and since he is sick...well she would know exactly what to use against him.