Board Thread:Theories and Speculation/@comment-34656247-20180531072459/@comment-33308438-20180614071311

To be fair, he(Itachi) is likely lying about the Izanagi and Madara being the first to unlock the Mangekyou Sharingan, probably. Tobi claimed it(Izanagi) can be awakened by Hashi's Cells and Uchiha-DNA, I believe. More/less, I think he(Hashirama) will likely have some sort of resistance, in the sense, he fought powerful Uchiha on a daily, probably.

I don't think it's likely to suggest, he'll subdue the Genjutsu, though. Zetsu claim's it's the strongest Genjutsu in existence, I believe.

There's this fun-fact that Tsukiyomi is labeled a form of Ninjutsu, and not exactly Genjutsu, in the Databook, I believe.

It's questionable the current methods in use, are sufficient enough, to suggest he'll subdue it, likely.