Kaguya Ōtsutsuki

Princess was the first human able to use chakra and was the mother of the Sage of the Six Paths.

Background
Centuries before the founding of the hidden villages, during an era of endless wars between man, Kaguya decided that it was necessary for someone to attain god-like powers in order to stop the conflicts. For this reason, she consumed the forbidden fruit from the Shinju, gaining the ability to manipulate powerful chakra and allowing her to single-handedly put an end to all the wars that plagued the lands. Kaguya later gave birth to a son, who was born with chakra of his own. The Shinju, furious with Kaguya's actions, was determined to get its chakra back and thus the Ten-Tails was born.

The Ten-Tails rampaged throughout the lands until Kaguya's son defeated and sealed the beast within himself, making him the first jinchūriki. Her son would later teach humanity the concepts of chakra, becoming revered as the Sage of the Six Paths.