Board Thread:Versus Debates/@comment-38643585-20190226232154/@comment-9782468-20190305225917

@FormalCarnage, it works exactly as I described. However, the chakra control necessary to store and then release that much chakra over large periods of times makes Tsunade the only capable user, and makes the difficulty rating S-Rank. Sakura managed to use STrength of a Hundred which works similarly, which Shizune commented that the chakra control necessary was insane. So no, not "every medical ninja" can use it. Shizune, Tsunade's apprentice for many years, never accomplished it.

So yes, she can use it more than once, and has already demonstrated doing so. It shortens her lifespan, but that just means she chooses how short her life will become, based on how often she uses it. It doesn't have a limit until she actually dies.

So thanks for the advice, but why don't you do more research on the series before lecturing me.