Board Thread:Versus Debates/@comment-34656247-20180714075601/@comment-4080775-20180714230721

Kabuto can do it if he plays his cards right. It took a forbidden dojutsu to incapacitate Kabuto and he put them in a genjutsu that took both of their MS to release (despite them being in Genjutsu; Inception maybe?) But yeah, he could incapacitate Tsunade rather easily and give Jiraiya and Orochimaru trouble.