Mikoto Uchiha

was the mother of Itachi Uchiha and Sasuke Uchiha and the wife of Fugaku Uchiha. While she was alive, she seemed to like Sasuke better where her husband seemed to prefer Itachi. She was a very good mother, seeing as how Sasuke was able to talk to her better than his father. At one point, in order to cheer Sasuke up, she says that when she and Fugaku are alone Sasuke is all he talks about. Although she was Itachi's mother, she did have some suspicion about Itachi and knew that something was up. She was found dead with her husband during the Uchiha Clan Massacre, killed by Itachi.

Trivia

 * In the character introduction of the Viz Media translation of Volume 25, instead of the name "Mikoto," she is simply credited as "Sasuke's Mother."
 * It is safe to say that Itachi and Sasuke get most of their looks from their mother rather than their father, except for the creases under Itachi's eyes.
 * She appears in episode 161, witnessing the infiltrators.