Board Thread:Versus Debates/@comment-27924662-20160408191148/@comment-26369387-20160408202624

Well, Kaguya has Infinite Tsukuyomi, so in genjutsu department she beats both Itachi and Shisui.

As for Sword of Totsuka, with combination of Byakugan and Rinne Sharingan, Kaguya should be capable of seeing it coming and dodge it. Or alternatively, she uses Yomotsu Hirasaka and opens two portals: one in front of her and other behind Itachi and Shisui.

So yeah, Itachi and Shisui are both dead.