Kāma

Kāma is a compressed backup of an Ōtsutsuki clan member's biological data that they can embed in the body of a chosen recipient, transforming them into a for the Ōtsutsuki's will should they sustain fatal injuries. Over time the Kāma overwrites the vessel's genetic profile until their body transforms into that of a perfect Ōtsutsuki, at which point the Kāma disappears and the Ōtsutsuki can take over their body and.

In the interim, the vessel can learn to activate the Kāma and utilise a portion of the Ōtsutsuki's power and abilities, at times even allowing the Ōtsutsuki's will to manifest and take control over their body.

Appearance
Though the Kāma superficially resembles a tattooed seal, it is actually a pyramid-shaped barb that is embedded in the vessel's body. Upon activation the visible marking will spread across the vessel's body, at times taking on different patterns depending on the abilities being used. Typically black, these markings may also shimmer and glow with a particular colour when activated, and when viewed up close appear to spread in patterns resembling microscopic circuitry.

Isshiki Ōtsutsuki

 * Jigen: Isshiki embedded his Kāma into Jigen's chin while parasitically fused with his brain, after being betrayed and nearly killed by Kaguya Ōtsutsuki. When activated it spreads across his face and body in nearly symmetrical sunburst patterns. Progressing further, he sprouts a long horn identical to Isshiki's.
 * Kawaki: Upon realising that Jigen's body would not be able to sustain his chakra, Isshiki transferred his Kāma into Kawaki's left palm through scientific experiments conducted with the aid of Amado. When activated it spreads across the left side of his body forming a pattern that almost perfectly mirrors Boruto's, extending up to his left eye, and then glows red. Progressing further, he sprouts a short horn resembling Isshiki's.

Momoshiki Ōtsutsuki

 * Boruto Uzumaki: Momoshiki embedded his Kāma into Boruto's right palm as the boy dealt a fatal blow to him using the Parent and Child Rasengan. When activated it spreads across the right side of his body forming angular and curving geometric patterns, extending up to his right eye, and then glows blue. Progressing further, he sprouts a horn similar to Momoshiki's and his right eye turns into a Byakugan.

Abilities
This mark apparently grants the wielder immense longevity, able to remain physically unchanged for centuries. When activated, Kāma significantly enhances the user's physical abilities and the power of their jutsu, and can absorb chakra and chakra-based attacks like ninjutsu. Kāma can also be used as a medium for Space-Time Ninjutsu, opening rifts to any location including foreign dimensions at will. This ability seems to be rather advanced as only Jigen was able to use it by himself, Boruto and Kawaki's needing to cooperate to use it instead.

Boruto's and Kawaki's Kāma exhibit when in close proximity. When their Kāma resonate, it apparently enables them to release anything that either of them had previously absorbed. This resonance seems to be coming from Kāma that are acquired from different sources, as Kawaki got his from Isshiki (via Jigen), while Boruto got his from Momoshiki. Jigen and Amado theorised that it was this resonance that allowed both Kawaki's and Boruto's Kāma to mature more rapidly than expected. Although Jigen is able to synchronise with Kawaki's Kāma to open a space-time rift, no such resonance exist between the two of them as Kawaki did not experience the sudden growth until his contact with Boruto.

Kawaki could activate it at will by the time he first met Boruto and three years later, Boruto was able to activate the seal at will as well, while Jigen was fully capable of activating it any time he desires. Boruto's resonated Kāma could also be forcefully activated when Kawaki activates his own nearby.

Through the aid of science, Isshiki was able to transfer his Kāma from Jigen to other individuals, albeit with a low rate of success, as of fifteen known test subjects, thirteen are confirmed to have died, with Kawaki the only known successful recipient. Jigen has also shown the ability to absorb chakra from creatures that are similar to tailed beasts and force Kawaki's Kāma to synchronise with his for him to open a portal to his location.

Manifestation
Under certain circumstances the Ōtsutsuki can manifest their will to possess the body of the vessel, causing the markings to change shape and the surrounding portion of their body to transform, undergoing changes that may include protruding Ōtsutsuki's signature horns and even activating their dōjutsu. This seems to only be possible after a great deal of time or as a result of resonance, and typically occurs during moments of heightened emotion or stress.

While Jigen can activate this state freely, Kawaki was only able to partially achieve it out of anger, with Jigen surprised by how quickly it progressed. Likewise, Momoshiki was only able to manifest through Boruto's body when the boy was knocked unconscious and nearly killed by Boro. Extended use of this form can greatly wear down the vessel's body: Momoshiki had to absorb Naruto's chakra to continue fighting until he killed Boro in Boruto's body and he soon collapsed. Additionally imperfect vessels can break down from the sheer power the Ōtsutsuki was using, as though Jigen could activate it willingly, he was unable to handle Isshiki's full powers for long and began breaking down after a while.

Resurrection
Over time, the vessel's own genetic information will be completely overwritten by the Ōtsutsuki biological data accumulated in the Kāma, at which point the Kāma will disappear and the Ōtsutsuki will resurrect, taking over the vessel's body and erasing their personality. This is the true purpose of Kāma, and allows the Ōtsutsuki to transcend death.

Drawbacks
Imparting a Kāma onto a candidate vessel requires a huge amount of energy to do so; when Isshiki was fatally injured by Kaguya, he did not have enough strength to apply one to Jigen at the time.

Using Kāma in battle could prove taxing for less skilled users, even more so when they are already weakened, as Kawaki quickly collapsed after using it against Garō as he was already injured from defeating Kara's robots while Boruto was left so badly weakened after using it for the first time that he collapsed and had to be helped to return to Konoha. Additionally, activating it seems to cause a not sufficiently experienced user some pain, as Boruto expressed pain whenever he activates Kāma. Jigen doesn't seem to suffer these weaknesses as he is much more capable at using them than either Boruto or Kawaki, as he never showed any reaction when activating Kāma and using it in his prolonged battle with Naruto and Sasuke had no effect on him. However, one known weakness of the seal that even Jigen seems to suffer from is that incomplete vessels could breakdown from channelling Kāma's full power, as after overpowering Naruto and Sasuke, the blackened section of his body cracked and he even cried soon afterwards and was forced to retreat back to be treated by Amado. If an Ōtsutsuki uses an inadequate vessel for a revival, the body will be unable to handle the enormous chakra, and die within a couple of days.

Kāma can only absorb chakra-based substances, hence non-chakra matter and energy such as viruses and natural flames can harm the wielder.

Trivia

 * Though its furigana reading indicates the pronunciation, its kanji spelling is given as , a Japanese tool resembling a wedge or linchpin, and its full appearance when not embedded in a host's body has a similar appearance and function.
 * "Kāma" means "wish", "desire", or "longing" in Hindu literature, and in Japanese it is also an uncommon way to write "karma." The latter is used as its official translation in Western media.
 * Sarada Uchiha has theorised, due to their similar appearance, that the Strength of a Hundred Seal may be related to it.