Board Thread:Versus Debates/@comment-30530312-20170403010718/@comment-26104757-20170407121328

Namikazenaruto9 wrote: I don't think it a good idea for tsunade to go against pretha path too. Because pretha path just has to catch her wrist and hold her down in a lock to absorb her 100 seals.(scenario similar to how pretha path absorbed naruto's Sage mode)

Unlike Naruto at the time, Tsunade is naturally strong, (having controlled Gamabunta's sword, even from the sky's height, not to mention she doesn't require chakra to use her explosive strength.) If he's able to evade Tsunade's destructive sequence and capture her, her brute force would break out of his hold without reasonable difficulty. From there, being at a close distant, all she'd need to do is retaliate with a one-hit knock out.