Board Thread:Naruto Discussions/@comment-25506982-20150218173901/@comment-5704511-20150219124426

before Kabuto goes all crazy about using Oro's power (all his extensive research, weird/nasty/creepy body modifications, all sorts of surprise techniques that they may have researched etc etc, a bookworm can be a nasty opp), he might have had some chance at defeating Kakashi (maybe 30-40%)... reason being, Kakashi's having Sharingan and decent skill with Ninjutsu. And all that they showed of Kabuto (before the war) was that he had formidable skill with medical ninjutsu, excellent chakra control, an ability to increase regeneration (Tsunade retrieval) etc, in this condition he (Kabuto) would have been defeated in a one-on-one match (in a region unfamiliar to both, Kabuto and Kakashi are both pretty intelligent).

However, after Kabuto changes... Kakashi will have only a lil a chance at winning (best shot maybe the Kamui, and the chances that he will succeed are barely in single digits XD maybe 10% at best). We have all seen how troublesome Oro was, even without Ninjustu, but Kabuto had access to that too.