Board Thread:Theories and Speculation/@comment-3365837-20160826052003/@comment-734582-20160827145346

Heliosraven wrote: Whoever says the seal weakens by every women who gives birth? If Uzumaki, the "ideal jinchuriki" suffer from it, it's safe to say everyone does. Heliosraven wrote: Hashiramas wife was the first jinchūriki and had children with him and she was from the Uzumaki Clan too. Judging from the age of Hashirama and the timeline, there's a good chance hashirama's wife already had children before becoming Jinchuriki, making this a non-problem. Even if it were, Hashirama would've been there to subdue Kurama with Wood Release anyway, so there's no way it would've been a problem.

Not sure about Hiruzen's wife, but Hiruzen had plenty of time to study the seals and develop countermeasures. I can't recall if we saw when Kurama was transferred between the two, it's possible Hiruzen already had kids similar to earlier.

Thirdly, if it hadn't been for Obito, Kushina's weakened seal would never have been a problem.

So, it's only a problem because of extreme circumstances. And since most Jinchuriki were outcasts, it's extremely doubtful being pregnant would be a problem to any of them.