Mito Uzumaki

was the wife of Hashirama Senju, the grandmother of Tsunade and Nawaki, and the first jinchūriki of the Nine-Tailed Demon Fox.

Background
The Uzumaki clan and the Senju clan, being distant relatives, had always had close ties. For this reason, Mito married Hashirama Senju, who would help found Konohagakure and become the village's First Hokage.

After Hashirama's victory against Madara Uchiha at the great battle at the Valley of the End, the Nine-Tails came into Konoha's possession. Mito used her clan's unique fūinjutsu and sealed the beast within herself in order to keep the threat that the Nine-Tails posed contained. Despite the seal's strength, it almost broke at some later point when she was going through childbirth. Eventually, her husband died in war, and Mito was left a widow.

Towards the final years of Mito's life, it was decided that a new host for the Nine-Tails would need to be found. Kushina Uzumaki, one of Mito's kinsmen, was then selected for the role due to her special chakra, and was terrified by the idea. Mito comforted her and, before the transfer was performed, told Kushina that love was the only way to counter the Nine-Tails' hatred.

Appearance
Mito was shown to have worn an elaborate kimono and a kind of tiara in her hair. Her hair was seen arranged in buns similar to Tenten and she had a diamond mark on her forehead, similar to that of her granddaughter Tsunade. She also has what appears to be seal tags in her hair decals.

Abilities
Not much is known about her fighting skills, but Kushina hailed her as a powerful kunoichi. She was proficient enough with fūinjutsu to seal the Nine-Tails within herself. Also, due to being a member of the Uzumaki clan, Mito had an exceptionally long life.

Quotes

 * (To Kushina)