Board Thread:Naruto Discussions/@comment-25122992-20170623182336/@comment-5085906-20170623185539

Itachi is definitely the best candidate. Even Hiruzen acknowledged that. Shisui also fits the bill, but I always got the impression he would work much better as an advisor to Itachi or a Shadow Hokage like current Sasuke.

Uchiha plagued by the Curse of Hatred like Fugaku, I would have made Hokage only in order to quell the rebellion at least temporarily until the village's echelon came up with a better solution to avert the Uchiha massacre.