Board Thread:Theories and Speculation/@comment-26545929-20150630030815/@comment-4061125-20150630040912

I'm gonna have to say Tsunade. She cannot be killed in battle due to her strength of a hundred seal which allows her to regenerate from any wound very quickly. Additionally, she has shown enough strength at full power to be able to shatter the ribcage of the Madara Uchiha's susano'o. She was also able to hold her own against him for a very long amount of time. She even punched one of his flame dragon jutsus to disperse it.

However, Orochimaru is a close second since he knows the impure world ressurection jutsu and is immortal. It's hard to say with him since we have never seen his strongest techniques because his hands were sealed for a long time and even when they weren't he was never in a fight where he was fully on the offense and trying to kill with everything he's got. We do know that he was a prodigy and he has exceptionally impressive defensive capabilities that go beyond normal ninja limits.

Kurama8923 wrote: You make some pretty good points, but Jiraiya was pretty well versed in jutsu like Fire style and Earth style where Tsunade only really has taijutsu and medical ninjutsu, not to mention he had Rasengan and Gallant Rasengan. Also Itachi even said that the best he could do against him is a draw with both of them dying and I think Itachi could easily beat Orochimaru and Tsunade considering how easy it was for Orchimaru to get caught in Itachi's genjutsu when he tried to take his body shortly after joining the Akatsuki.

I would disagree as Tsunade managed to briefly overpower Madara even with Madara having Hashirama's cells and the rinnegan. Madara was a lot more powerful than Itachi and therefore, I think Tsunade would wipe the floor with Itachi unless Itachi used the Totsuka blade. However, in that case, Itachi could win again Orochimaru and Jiraiya as well, simply by sealing them in the blade.