Hisame

is a missing-nin from Amegakure in the Naruto OVA 2.

OVA 2
She is said to be the most intelligent of Amegakure's ninja. Hisame left her village behind to help Suien seek the Hero Water of the Takigakure. She assisted Murasame into taking down Sasuke Uchiha while Naruto Uzumaki pursued Shibuki. Hisame was defeated when Shibuki drank the Hero Water to fight back against Hisame and her fellow attackers with a Water Dragon technique. Her status after that is unknown.