Board Thread:Theories and Speculation/@comment-24901923-20161130025154/@comment-734582-20161130085714

Considering that Minato sealed Kurama and then himself via Shinigami seal and then got the first layer unsealed by Orochimaru but kept Kurama inside him, i guess the answer is "yes".

The biggest problem with this kind of technique is simply preparation. With the kid of time you spent making these techniques, you're pretty much better off training regular techniques.