Board Thread:Theories and Speculation/@comment-39172349-20190512222106/@comment-9782468-20190513155112

No.

Shisui's eye was set to come out in response to Itachi's MS.

Itachi's Amaterasu sealed into Sasuke was set to respond to Obito's Sharingan.

So at best, Kakashi would get severely burned/killed by Amaterasu. But Shisui's eye wouldn't come out because Itachi's eye wasn't among them.