Board Thread:Naruto Discussions/@comment-26210090-20150315213729/@comment-1458758-20150315231529

It's probably noteworthy that all the people whose limbs have been replaced using Hashirama cells or Whit Zetsu parts (that didn't explode horribly like Danzo) are direct descendants of Hagoromo. It's likely that if Guy went through this process it wouldn't be entirely stable. Having said that, Naruto just about managed to save him, so even if they repaired or replaced the leg, we don't know the damage to his body/chakra network entirely, so it could be that he might've 'burnt out' his system entirely, and the leg is just the worst of it, making replacing it while the rest is still buggered kinda pointless.