Board Thread:Versus Debates/@comment-26104757-20170303072554/@comment-30426414-20170304042512

Slug Princess00 wrote: Wouldn't Mei's Hiding in the Mist technique be enough to defeat him? Since the Sharingan will be weakened

He can still see chakra so its no advantage for them either, it just means he can't use genjutsu.

, added to his already blind and deaf status, it would leave him entirely open for Tsunade to lower in with her introductory Heavenly Kick of Pain.

Are we not assuming itachi starts out fresh in this battle? I don't see a reason for him to use his mangekyo until the time he deems its necessary to deal the killing blow.

If he opens MS, and uses Susanoo, Mei can incorporate her vapour and melt his defense, enough for Tsunade to break through.

That jutsu isn't melting through a full armored susanoo. Not to mention they are not in an enclosed space so its less effective because the concentration will be lower.

Mei trumps his Fire power.

Amaterasu says otherwise.

Tsunade will likely be able to escape any Genjutsu he uses courtesy of her perfect chakra control.

Any genjutsu except tsukuyomi which affects take place in such a small window of time that any normal means of breaking it are left ineffective.

BTW: How long can Itachi leave his MS open before he kneels over with exhaustion?

Depends on if he has the sickness or not. If he doesn't, then probably as long as sasuke.