Board Thread:Theories and Speculation/@comment-27082825-20150116155842/@comment-1458758-20150122233715

Iar Sensei wrote: I didn't see your post earlier. I wish I did. So by this theory, any 3 element combinations could prodce a kekkei tota? Yes, essentially, but the core of the idea is that unlike Kekkei Genkai, which can occur naturally, people are just born with said ability as with Haku, it would be my suggestion that that reason there are only two people in the world with a Kekkei Tota is that they were specifically engineered/bred to have it, that the possibility of such an ability cropping up naturally is virtually none.

Looking at the evidence on hand, the only examples of similar abilities are Kekkei Genkai which only contain two elements or are a unique mutation (Sharingan, Kimimaro's bone thing), or ones that encompass all of the base natures, like Itachi's Yata Mirror or the Truth Seeking balls etc.

So the rarity of the ability, the knowledge of background on the Naruto world and its politics and all other evidence on top of that leads me to believe that the Kekkei Tota, by its very definition, is an ability that was artificially produced within Iwagakure and, in theory, could be replicated, but only by producing people with the same selective traits.