Board Thread:Versus Debates/@comment-27418151-20160528023643/@comment-734582-20160528184039

Hashirama too stands little chance. The serum used on Yamato would rob him of wood release and weaken him massively. And Kabuto extensively researched Hashirama's cells, it's doubtful Hashirama can do much that Kabuto can't already counter.

The only real chance Hashirama has here is if he has previous knowledge. Else he'll be caught offguard to ridiculous degrees, since he's not clairvoyant. Kabuto would finish him before Hashirama realizes who exactly he's facing here.

Not to make Hashirama sound weak, but in Naruto, counters are a real thing, and Sage Kabuto is basically his biggest counter.