Board Thread:Versus Debates/@comment-3523655-20191203173415/@comment-43403813-20191204133151

In the state that she was in when she stepped up against Pain, she would have gotten stomped. She was exhausted of almost all of her chakra when she protected everyone against the Shinra Tensei that destroyed the village; she became extremely frail and unwell for a very long time after Pain's invasion.

Now, if she was at full power with her Mitotic regen technique, she would have fared much better. I still think the outcome would be that Pain would win, but I reckon she would take down the Preta Path, Naraka Path and probably Human Path with ease.

Asura Path maybe not, since Nagato reacted to Killer Bee with it who has faster CQC speed than Tsunade, so her punches might be stopped by restraining wires and mechanical arms. However, Tsunade could maybe pull it off considering Pain had dulled reaction speeds as a result of the big Shinra Tensei.

If Tsunade could get close to him, the Deva Path would be taken down easily at the point of the fight you're talking about, since his abilities hadn't returned yet. But if they did, Deva has a pretty good counter to Tsunade, he'd just keep repelling her with Shinra Tensei whenever she would come close, or he would use Bansho Tenin to pull her into the clutches of the Human Path. Although, it's easy to assume that Tsunade could just punch the Human Path. In terms of any damage she sustains from the rockets and missiles, she would regen quickly so it wouldn't be too much of a problem for a while. In terms of the chakra rods though, yes she would recover from them, but they would disturb her chakra, so she would not be as efficient with it.

Tsunade would have trouble with the Animal Path as well, all the summonings would pressure her quite a bit, her only option would be to try and hit the summoner Pain, but that might be difficult given that she would need to bypass all the summonings and the other Paths of Pain.

I don't think Tsunade would perform as well as Jiraiya. Jiraiya utilised an offensive summoning, and I can't recall any offensive summonings on Tsunade's part. Katsuyu is quite passive and wouldn't be able to help Tsunade out against the plethora of summonings Pain has up his sleeve. Jiraiya also had Sage Mode, albeit imperfect, but it is a difference nonetheless.

All in all, I think Prime Tsunade against Pain would still lose, taking out 3 Pains at best, 4 if Deva doesn't have his powers back. Realistically, if Pain resorted to it, Tsunade has nothing on Chibaku Tensei.