Board Thread:Naruto Discussions/@comment-434627-20160705183726/@comment-25009130-20180223183614

Ianmathwiz7, Obito said you need both Senju and Uchiha DNA to perform it to it's fullest (This comes from the Wiki page, which cites the same chapter and pages you do. But back to the point, for a single reversal of death it would be sufficient. Danzo's use (and also Obito's) allowed them to continuously use it for a certain duration, and any damage or death done to them in that time was reversed. Without the Senju DNA, you can still use Izanagi, just not for quite as long. You also need complete control over the Senju cells to perform it to it's fullest. Thats what Obito noted, that Danzo didn't have complete control and thus couldn't use it to it's full capacity.