Nagato solos. Itachi can’t I don’t think but he’d be overkill in this situation.

Alive healthy nagato>edo nagato>>>pain>>>jiraya≈orochimaru>tsunade

Basically a shit ton more chakra and better chakra control for an experienced rinnegan user who’s also ludicrously fast. Edo nagato(every edo is physically weakened)was keeping up with kcm1 naruto who’s faster than the raikage who is arguably faster than jirya, the fastest member of the sannin.

Cant see any one of the sannin even approach him with universal pull/push at the crazy high reaction speeds he already has, any jutsu be viable against absorption, or them living through meteors falling from the sky or getting sucked into the middle of a giant ball of rocks.

I think I’ve said this before but I genuinely think a healthy nagato is like a bootleg edo madara without the obviously higher feats and stats.

What the dude above me said

Whatever the dude above the dude above me said

@Dyss00 is going to say stuff for Orochimaru most likely carrying this, but Tsunade could honestly hold her own against Nagato or Itachi. she's cracked the susanoo ribcage and survived getting stabbed multiple times by wood clone susanoo sword. and dyss says that Orochimaru is much much higher so...

@Sonofseagods i aint seeing tsunade punching her way out of chibaku tensei lol

Nagato and Itachi mega slap.