Bee is able to fight on par with Kcm Naruto and V1 Ay in reactions, so he should be more reflexive than the paths who at best have SM Narutoish reactions.
However, soul rip/black rods are still dangerous for Bee who doesnt know wtf those are, let alone know how to counter them, and given Bees nature of being casual; this might cost him an L.
But, V1-V2 Bijuu transformations are VERY dangerous for Pain given how Bee was able to blitz Nagato with his lariat.. but Bees lack of knowledge about the path reviver helps him a lot..
CT is a GG for Pain but Bee might be able to kill him before he launches it off.. I’d say it can go either way with Pain having a slight advantage.