In terms of physical strength, by no means is Danzo a weak ninja, since he is empowered by Hashirama cells. Still, even his enhanced strength was no match for Sasuke's Susanoo ribcage, which Ay managed to break through. He also wasn't fast enough to dodge Amaterasu, in fact he was completely caught off guard, so he definitely is not as fast as Ay. His most impressive speed feats are managing to place a seal on and briefly choke Sasuke when they clashed, although Sasuke still won, dodge an attack from the latter's Skeletal Susanoo, and barely manage to evade Sasuke's Susanoo arrow, like Tim Xman said. The only other times he really caught Sasuke off guard was when he had to deal with Baki and Danzo flanked him, and after Danzo was revived after using Izanagi and he spawned (for lack of a better term lol) behind Sasuke and used Vacuum Bullets, so I wouldn't really count that last one as a speed feat.
His jutsu have pretty solid power though, they were able to cut Sasuke, and with the help of the air vacuum Baki was producing, he managed to severly damage Sasuke's newly evolved Humanoid Susanoo, to the point where its spine was exposed. Even when his body started dying and he couldn't control his Hashirama cells anymore, which caused him to lose an arm, he still managed to tank a Chidori sword and Chidori Sharp Spear from Sasuke, as well as enough chakra to pull off one final seal. He also managed to dodge a severly weakened Sasuke who was charging at him with a Chidori, and get behind and put Karin in a chokehold in the process. I'd put him in the middle of Low Kage.