Hyuga/Kaguya are the descendants of Hamura, and Uchiha/Uzumaki are the descendants of Hagoromo, so why don't we pitch the prodigies of each side together? Left out Moon Otsutsuki and Senju for obvious reasons.
Participants:
Neji: Prodigy and strongest of his clan.
Kimimaro: Prodigy and strongest of his clan. Also the only "survivor" of his clan.
Sasuke: Prodigy and strongest of his clan. Also the only survivor of his clan.
Karin: Prodigy maybe and probs the second strongest of her clan. Also the only member of her clan that actually uses her clan's abilities.
Restrictions:
Genjutsu is not allowed because Sasuke. Animal summonings are not allowed because Sasuke. In addition, Curse Mode is not allowed because I want them to use purely their original/clan's abilities. Susanoo and Adamantine Chains are not allowed though, because they're too OP.
Settings:
This is during the war before Sasuke "died", so everyone has knowledge and abilities up to there, which means Sasuke can use EMS. Kimimaro is not an edo, so he can be killed, and he's not sick. The battlefield is an open grass field.
My Opinion:
At first it might seem that Sasuke can just one shot all of them with Amaterasu, but Neji can release chakra from all tenketsu, which could possibly work just like Shinra Tensei. Kimimaro can also just cover himself with protruding bones so he can remove them if they got caught.