What if Kushina used the Dead Demon Consuming Seal herself to seal Kurama's Yin and Yang halfs in Minato and Naruto, respectively? I'll talk a little about what would change in my opinion.
In this case, Minato would survive and continue his administration as Fourth Hokage. I think he'd likely veto the Uchiha Clan isolation, controlling its revolt and consequently avoiding the Uchiha Clan Downfall.
With Itachi still in Konoha and both Itachi and Shisui still alive, Sasuke wouldn't awaken his Sharingan so early. Instead, he'd likely train with Itachi himself at somepoint of the story.
Also, Naruto would be named Naruto Namikaze as Minato would be alive to protect him from his enemies. Naruto wouldn't be hated by the villagers for carrying the Nine-Tails, as Minato would've claim to be the Jinchuuriki of Kurama in order to protect his son. Not being rejected by the village, Naruto would grow as a normal kid, not pranking the Hokage Monument, for example.
Did I forget something? Do you disagree with something I said here?
Edit: It's likely impossible to seal something in someone else with the RDS, but Kushina could still use the Eight Trigrams Sealing Style to seal it in Minato, who could later use another seal to give part of this chakra to Naruto.