No one could really tell who will win. Tobirama is so much underrated when it comes to manga and anime. We will only rely on Madara's portrayal and description of Tobirama in his prime Tobirama in his prime is not feared as there are many ninjas who are also powerful and near kage levels during that time. Minato with his speed ang jutsus will make us think he is above Tobirama but isn't enough of a proof.
So let's summon the Third, Sarutobi. He might be the only one to answer this question.