""Know Pain"" (｢痛みを｣, "Itami o") is chapter 429 of the original Naruto manga.
The Human Path kills Shizune and relays Naruto's location to the other Six Paths of Pain. The Animal Path leaves the village while the Deva Path, intending to punish Tsunade for defying a god, leaps into the air. Meanwhile, Naruto learns that Kōsuke had died, meaning something has happened in Konoha, and prepares for battle. The Animal Path summons every Pain but the Deva Path to a safe distance away from Konoha while the Deva Path uses its Shinra Tensei to destroy Konoha. Simultaneously, Shima summons a coalition to the village's centre.