'Shaking my head'
Let's get 100% correct here: Assuming the thing from anime is the same in canon, that Hagoromo and Hamura's father was a human is correct, then Hagoromo and Hamura were already only 50% Otsutsuki 50% human.
In that case, Asura and Indra were only 25% Otsutsuki already. Being reincarnation of either son doesn't make one have the same genes. The reincarnations simply have Asura's/Indra's chakra mixed in with their own. So theoretically, purely in terms of power, the Asura and Indra incarnates are partial resets of the bloodline's power, but not biologically.
Naruto and Sasuke are 99,999999999999999999999% human, since not only they are descended from people who already had only 1/4(25%) alien genes, but over 1000 years has passed since, that's far too many generations and mixing with ordinary humans to consider them part anything.
They are simply humans with alien ancestry, possibly having a few odd genes in here and there. Let's not forget that in all likelihood, descendants of Asura and Indra and descendants of Hamura's children must have on occasion bred with others outside of their clan, thus whatever may have remained of the alien genes has possibly spread to a considerable part of human population.
In other words, a considerable part of Naruto human population today in one way or another descends from Kaguya, if not the very majority even.
So taking look at the clans, the 'least human/most alien' people in recent times would be the Kaguya Clan due to their non-ordinary body structure and skeletal power inherited from Kaguya, the Hyuga Clan, literally possessing genes for alien eyes and the Moon Otsutsuki. Followed right after with Senju, Uzumaki, Uchiha and whatnot distantly related clans and individuals to these, along with Kinkaku and Ginkaku.
In other words, biologically speaking, Boruto is 99,99999999999999x% human and so is Sarada. Power wise, they are children of reincarnations of Asura and Indra who were further empowered, so in terms of chakra, right after Naruto and Sasuke of course, they are the closest to Asura and Indra, yes.