not to mention she can always augment her reflexes if necessary. if she has precise enough control to alter a person's synaptic relays like she did with kabuto, she should be able to easily alter her relays so that her reflexes are faster. another thing must be stated. the elders wanted jiraiya to become hokage because he was the only one in the village capable of doing the job, but he didn't want non of that so he specifically said there is another and that was tsunade meaning there is no real reason to ask the question of who would win
i would also like to add that a simple look at there databook stats should give you the answer. and i know people on here don't like putting stats but the stats are canon and a good guide to use the first databook gives hiashi a rating of 3.5 in ninjutsu. 4.5 in taijutsu. 2 in genjutsu. 3 in intelligence. 3.5 in strength. 4 in speed 4 in stamina and 5 in hand seals with a total of 29.5
the first databook gives tsunade a 5 in ninjutsu 5 in taijutsu 3.5 in genjutsu 5 in intelligence 5 in strength 3.5 in speed 4 in stamina 4 in hand seals with a total of 35.5
even if we do not take into consideration the stats she is a senju and has loads of chakra as well as loads of strength and more experience in warfare