The cursed seal is placed directly on the target's heart and by design, prevents the branded individual from taking their own lives or removing the cursed seal themselves. A direct strike to the heart appears to be able to remove the seal — albeit risking one's life in the process. According to Obito Uchiha, the cursed seal also interfered with him becoming the Ten-Tails' jinchūriki.
- Both Rin Nohara and Obito Uchiha, who were branded with this cursed seal, had it removed by Kakashi Hatake's Chidori and Lightning Cutter respectively, although Rin died while Obito survived by sealing the Ten-Tails into himself shortly after.
- In the manga, the tag is black, with a Rinnegan-like symbol on it, while in the anime, it is white, with a red, white, and teal symbol.