The cursed seal is placed directly on the target's heart and by design, prevents the branded individual from taking their own lives or removing the cursed seal themselves. A direct strike to the heart appears to be able to remove the seal — albeit risking one's life in the process. According to Obito Uchiha, the cursed seal also interfered with him becoming the Ten-Tails' jinchūriki.
- Both Rin Nohara and Obito Uchiha, who were branded with this cursed seal, had it removed by Kakashi Hatake's Chidori and Lightning Cutter respectivelty , although Rin died while Obito survived by sealing the Ten-Tails into himself shortly after.
- In the manga, the tag is black, with a Rinnegan-like symbol on it, while in the anime, it is white, with a red, white, and teal symbol.