"Hashirama's Cells" (柱間細胞, Hashirama Saibō) is episode 351 of the Naruto: Shippūden anime.
Kakashi is still plagued by nightmares and as a result becomes even more sullen than before. Seeking answers about Kinoe's abilities, he breaks into the Hokage Residence where he is caught by Hiruzen. The Third explains a bit about the history of Hashirama Senju along with the village's initial experiments to keep the Wood Release kekkei genkai alive, and the subsequent disappearances. Elsewhere, Danzō plots to have Hiruzen assassinated on his way to the Fire Daimyō, however, his plans are foiled when Kakashi warns the Hokage of the plan. During their brief confrontation, Kakashi releases Kinoe informing him that one day his abilities would prove useful to the village. Reporting to Hiruzen, Kakashi ultimately accepts a post as an Anbu under the Third's direct command before informing him of Kinoe's existence. Genma, Raidō, Asuma, Kurenai, and Guy discuss the changes that had once again been made and despite being saddened that Minato had passed, still wished the best for Hiruzen and the future of the village.
- During a shot of countless fallen Uchiha and Senju clan members, one of the fallen Uchiha clan members greatly resembles Sasuke Uchiha, both in hairstyle and clothing.
|Role||Seiyū||English Voice Actor|
|Kakashi Hatake||Mutsumi Tamura||田村 睦心||Tamura Mutsumi||Dave Wittenberg|
|Minato Namikaze||Toshiyuki Morikawa||森川 智之||Morikawa Toshiyuki||Tony Oliver|
|Third Hokage: Hiruzen Sarutobi||Hidekatsu Shibata||柴田 秀勝||Shibata Hidekatsu||Steve Kramer|
|Danzō||Hiroshi Ito||糸 博||Ito Hiroshi||William Knight|
|Kinoe||Eri Goda||合田 絵利||Gōda Eri||Colleen O'Shaughnessey|
|Might Guy||Mayuki Makiguchi||牧口 真幸||Makiguchi Mayuki||Skip Stellrecht|
|Asuma Sarutobi||Fujiko Takimoto||瀧本 富士子||Takimoto Fujiko||Doug Erholtz|
|Kurenai Yūhi||Megumi Han||潘 めぐみ||Han Megumi||Mary Elizabeth McGlynn|
|Genma Shiranui||Mariko Higashiuchi||東内 マリ子||Higashiuchi Mariko||Johnny Yong Bosch|
|Raidō Namiashi||Yuko Takayama||髙山 ゆうこ||Takayama Yūko||Patrick Seitz|
|Fire Daimyō||Yoshiyuki Kaneko||金子 由之||Kaneko Yoshiyuki||Grant George|
|Konoha Anbu||Shinobu Matsumoto|