This orphanage is seemingly located on the outskirts of Konohagakure. It was run by a number of wardens, one of which was Nonō Yakushi — one of the captains of the Medic Corps and former member of Root. This orphanage took in children from different parts of the nation and taking care of them. During wartime, the orphanage also helped out the Konoha shinobi acting as a medical centre where the shinobi would come for treatment. It was also revealed that once old enough, the children of this orphanage could train as Konoha shinobi.
Danzō Shimura, Orochimaru, and Tatsuma Aburame — visited the orphanage at some point during the Third Shinobi World War, and blackmailed Nonō into undertaking a mission for the organisation. Kabuto, who was a ward of the orphanage joined the organisation after Danzō noted that he needed someone to take the place of a Root member that was slain.
After the Fourth Shinobi World War, Kabuto returned to the orphanage as a caretaker, working alongside his childhood friend Urushi. By the time of the Seventh Hokage's reign, the orphanage had expanded in size — adding several more buildings to its structure. After Shin Uchiha's clones were subdued by Naruto, he decided to send them to the orphanage to stay.