Is Koto used? If so, this is over with a simple jutsu. If its a simple fight, Shisui was stated to beat him.

Koto is Shisui's only chance, the end (Koto is unsolvable enigma and we can't say for sure who will win).

@Minat, how could Itachi defeat a better Genjutsu user then him? Shisui was stated to be the best Genjutsu user of his time which included Itachi. Shisui has controlled multiple people using Genjutsu out of a Sensors range, hundreds of feet away, meaning he doesn't even need to see Itachi to get him. Itachi is an amazing Genjutsu user, but no Genjutsu feats compare to Shisui's.

If kotoamatsukami isn't restricted than shisui wins without question. I'm pretty sure kotoamatsukami doesn't require eye contact either based on Danzo's use.

Does this mean last seen Shisui becuause since then Itachi has gotten mangeyko plus at the last time you see shisui he has no eyes. This is why no matter what Itachi will win because he had susanoo with Amaterasu while Shisui only had regular susanoo. This is why I think Itachi would win

Shisui doesn't have susanoo, his susanoo is game exclusive therefore it's not canon.